Valencia began life without fired coach Miroslav Djukic by scraping into the Copa del Rey last 16 with a 1-0 victory over Gimnastic.
Having been held to a goalless draw on the road in the first leg, Valencia will have been feeling more than confident about sealing their progression on home turf against third-tier opposition.
However, that proved to be easier said than done, as the hosts - under the temporary charge of Nico Estevez - struggled to break down their visitors at a sparsely populated Mestalla.
Paco Alcacer handed the Liga side the advantage in the 37th minute, before a foul on Pablo Piatti in the area late on offered substitute Helder Postiga the opportunity to double Valencia's lead from the spot.
But it proved to be an opportunity wasted as Tomeu Nadal got down well to keep out the strike and restrict Valencia, who will now take on Atletico Madrid, to a one-goal victory.
At San Mames, Athletic Bilbao stormed to a 4-0 victory over 10-man Celta Vigo to sail into a last-16 meeting with Real Betis, prevailing 4-1 on aggregate.
Iker Muniain put the hosts in front after 21 minutes, smashing home from the edge of the penalty area after a delightful flick by Aritz Aduriz.
Markel Susaeta doubled that advantage a minute short of the break, with Hugo Mallo dismissed early in the second half, before a second Muniain strike and one for Aduriz put the result beyond all doubt.
Elsewhere, Espanyol imposed their superiority as they overcame Segunda Division Real Jaen 2-0 to seal a 4-2 aggregate victory.
Simao opened the scoring for the hosts in the 12th minute, before Sidnei's strike five minutes from time secured a showdown with second-tier Alcoron.
Real Valladolid's Javi Guerra played the part of both hero and villain as his side crashed out 3-1 to Rayo Vallecano.
Following a goalless first leg, Guerra drew first blood by sending the visitors into a 28th-minute lead at Estadio del Rayo Vallecano, before Adrian drew the hosts level four minutes later.
Guerra was shown a straight red card three minutes into the second half and Valladolid failed to recover from that setback.
Adrian put the hosts ahead in the 87th minute with his second of the match, before Alberto Bueno made absolutely certain of the win in stoppage time.
Rayo will meet Levante in the next round.
|Coach: Nico Estévez|
for É. Banega 69'
for F. Cartabia 70'
for Juan Bernat 78'
|Martial never the same again - Mangala|
|Copa del Rey Review: Racing fall at the first|
|Shelvey dismisses talk of England snub|
|Galatasaray unable to play Grosskreutz|
|Faroe Islands v Northern Ireland: O´Neill preaches patience ahead of Euro double-header|
|Levy slams ´wholly inappropriate´ West Brom after Berahino chase|
|Panama v Uruguay: Visitors without Suarez and Cavani|
|Captaincy won´t change me - Robben|
|Liverpool sign Brazilian youngster Allan|
|PFA expects swift Berahino resolution|
|Argentina v Bolivia: Mascherano backs ´very special´ Messi|
|´I do not know if I´m worth €80million´ - Martial shocked at price-tag|
|Afellay suspension reduced|
|Noble red card rescinded|
|Portugal v France: Deschamps aiming to correct mistakes|
|Bahebeck given the all clear|
|Germany v Poland: Muller out to settle the score|
|Gibraltar v Republic of Ireland: Keane counting on McCarthy and Walters|
|Georgia v Scotland: Tbilisi trip has must-win feel for Robertson|
|Juve still the team to beat - Hernanes|
|De Gea will remain professional, says team-mate Mata|
|Berahino given extra time off following strike tweet|
|´No excuses´ as Costa seeks to kick-start season|
|I´m not like Messi or Ronaldo – Hazard|
|United States v Peru: Klinsmann out to ´prove a point´|
|Martinez unsure when Cleverley will return|
|France set for Russia friendly ahead of Euros|
|Former Manchester United forward Berbatov joins PAOK|
|De Gea must play to earn Euro 2016 spot – Del Bosque|
|Cahill thrilled to lead Socceroos|
|Wijnaldum urges patience with new-look Newcastle|
|Reid praises Stones´ professionalism|
|Mexico v Trinidad and Tobago: Islanders hoping to build on Gold Cup display|
|Choosing Brazil over Spain was easiest decision, says Rafinha|
|Galliani hails ´changed´ Balotelli|
|OFC World Cup Qualifying Review: American Samoa notch second competitive win|
|Canada v Belize: Hosts look to stay calm|
|Carragher surprised by ´big´ Martial price|
|No pressure on Rodgers - Rush|
|No Benzema, no Cavani - Arsenal ´can´t compete´ says Sol Campbell|
|FFA muzzle Postecoglou after pay dispute criticism|
|Celtic complete Simunovic signing|
|Joaquin: I´m as happy as a little boy|
|Navas given time off by Costa Rica|
|Martial unfazed by prospect of United pressure|
|Ramos urges De Gea to overcome transfer woe|
|Premier League spending hits £1bn in 2015|
|Italy v Malta: Conte calls for focus|
|De Laurentiis reveals failed Juve bid for Hamsik|
|Schweinsteiger: Manchester not as bad as everybody thinks|
|Galatasaray finalise Grosskreutz deal|
|Ilori agrees season-long loan with Villa|
|Wolfsburg want to ´annoy´ Bayern - Dante|
|Norwich bring in Jarvis on loan|
|Everton sign Lennon on permanent deal|
|United put blame back on Real Madrid over De Gea|
|Premier League Deadline Day: Berahino on strike, United make Martial number nine|
|Peace: West Brom must repair damage caused by Tottenham´s Berahino pursuit|
|Dyer secures loan switch to Leicester|
|Walters mocks deadline-day culture|
|Derby complete Johnson deal|
|Hector signed by Chelsea and loaned back to Reading|
|Watford secure Ibarbo loan|
|United´s Martial offer too good to reject - Monaco chief|
|No regrets over failed Juve move - Draxler|
|Guedioura returns to Watford|
|Berahino tweet casts doubt on West Brom future|
|Yedlin loaned to Sunderland|
|United complete Martial swoop|
|Strootman undergoes surgery again|
|FIFA set to clarify proposed Grosskreutz deal|
|Watford bolster strikeforce with Oulare|
|Belgium v Bosnia-Herzegovina: Time running out for visitors|
|Antonio makes West Ham move|
|I want to feel important at Leverkusen - Hernandez|
|Villa seal deadline-day swoop for Lescott|
|Austin to stay at QPR|
|Everton´s Gibson given driving ban|
|David de Gea: Timeline of Manchester United goalkeeper´s failed Real Madrid move|
|Southampton complete Van Dijk swoop|
|Bournemouth complete Murray deal|
|Real take aim at United over failed De Gea move|
|Premier League Deadline Day: West Ham bring in three, De Gea set for United stay|
|Reports: Real Madrid will not appeal De Gea transfer collapse|
|FIFA quiet on ´confidential´ De Gea paperwork|
|Chelsea sign Nantes defender Djilobodji|
|West Ham land Jelavic|
|Anthony who? Rooney had to ask who Martial was, says Schneiderlin|
|Moses joins West Ham on loan|
|Netherlands v Iceland: Blind era begins in Amsterdam|
|Deportivo snap up Gutierrez|
|Newcastle´s Kemen returns to France|
|Everton wrap up Funes Mori deal|
|Cyprus v Wales: Difficult to overestimate Bale contribution, says Davies|
|Blaszczykowski ´never considered´ Schalke move|
|Di Maria opens up about Van Gaal ´rows´|
|West Ham seal Song loan|
|Australia v Bangladesh: Luongo excited by Rogic partnership|
|Maturity, fitness vital for Shelvey|
|South Korea v Laos: Hwaseong hosts hunting goals|
|Japan v Cambodia: Hosts out to arrest four-match slump|
|Troisi joins Saudi giants Al-Ittihad|
|Casemiro lauds Benitez after re-signing|
|Rojo wants United stay|
|Milan tried for Witsel - Galliani|
|Conte eyes two Italy wins|
|Ligue 1 Deadline Day: Marseille sign three amid Martial saga|
|La Liga Deadline Day: Uncertainty over De Gea future, Joaquin back at Betis|
|Serie A Deadline Day: Juve and Inter busy as window closes|
|Layun swaps Watford for Porto|
|Joaquin makes Betis return alongside Van Wolfswinkel|
|Coventry City 2 Southend United 2: Ricketts salvages point for hosts|
|Real face anxious wait over De Gea as window shuts|
|Milan loan Mastour to Malaga|