Bayern Munich may be reeling when they host Hamburg on Saturday after suffering just their third defeat of the year in midweek.
Manchester City came away from the Allianz Arena on Tuesday with all three points in the sides' final UEFA Champions League Group D clash, but the 3-2 scoreline was not enough to knock the Bavarians off top spot in the pool.
The loss will have been doubly galling for Pep Guardiola, having seen his side race into a two-goal lead in just 12 minutes.
Heading into the game, Bayern had won their previous 10 Champions League matches - a tournament record - and secured victories in each of their 19 fixtures at the Allianz.
They are 40 unbeaten in the Bundesliga, and had lost just twice previously in 2013 - to Arsenal in the Champions League in March and Borussia Dortmund in the DFL-Supercup in July.
And Guardiola's side will take confidence from their recent meetings with Hamburg having won the last three - including last term's 9-2 mauling in the corresponding fixture.
Attacker Thomas Muller believes the Manchester City defeat proved Bayern are not invincible - but challenged his colleagues to use it to inspire them to get back to winning was at the weekend.
"The normal human in all of us came to the surface," the Germany international said.
"We were too casual. We made a great start but let them back into it. We need to regain our utter desire to win."
Hamburg have not beaten Bayern away from home since April 2007, and their recent form has been patchy with three defeats in their last six outings.
Former Netherlands coach Bert van Marwijk has overseen four wins from his 10 games in charge since replacing Thorsten Fink in September - only lifting the club from 15th to 13th in the process.
Despite their stagnating progress, former Bayern full-back Marcell Jansen is not prepared to head to Bavaria with damage limitation in mind.
He told Hamburg's official website: "Bayern follow a clear concept and will do the same against us. We all have to play to our limit and everyone in the team must defend well.
"As a player you have to believe in your chance, otherwise there is no point in going there. That is how we will be approaching the game."
First-choice goalkeeper Rene Adler is a doubt having struggled with an ankle injury in the week, while Ivo Ilicevic has also been missing due to personal reasons.
Captain Rafael van der Vaart returned to training on Tuesday, however, after recovering from an ankle injury and off-field issues.
Bayern will be without long-term absentees Arjen Robben, Holger Badstuber (both knee) and Bastian Schweinsteiger (ankle), but have been boosted by recent returns of Xherdan Shaqiri and Claudio Pizarro.
|5||D. Van Buyten|
for M. Götze 64'
for T. Müller 78'
for T. Kroos 82'
|FFA hands Wanderers fine and suspended points deduction|
|Luis Enrique: I had to give my voice a rest|
|Silva: I was not kicked off Marseille team bus|
|Blanc could sign PSG renewal by end of week|
|PSG drawn against familiar foes Saint-Etienne in Coupe de France|
|Neville confident Valencia fans will be back|
|Guardiola praises beaten Bochum|
|Coupe de France Review: Ibrahimovic sends PSG through, Nantes win thriller|
|I love penalties - West Brom´s shootout hero Foster|
|Ross County 0 Hearts 3: Dauda dazzles in valuable victory|
|Bayern Munich avoid Borussia Dortmund in DFB-Pokal semi-finals|
|FC Heidenheim 2 Hertha Berlin 3: Ibisevic at the double in DFB-Pokal|
|Hart: We will fight for Pellegrini all the way|
|Peterborough United 1 West Brom 1 (aet, 3-4 on pens): Foster spares Premier League team´s blushes|
|Paris Saint-Germain 3 Lyon 0: Ibrahimovic fires holders into last eight|
|Valencia 1 Barcelona 1 (1-8 agg): Kaptoum breaks record with late leveller|
|Bochum 0 Bayern Munich 3: Lewandowski double helps book semi-final spot|
|Colour clash forces Stoke to produce new kit|
|Hernandez to miss Darmstadt match with muscle injury|
|Stoichkov backs ´smart guy´ Neymar to stay at Barcelona|
|FSG´s letter of apology to Liverpool fans in full|
|Huracan bus overturns following Copa Libertadores clash|
|Liverpool scrap ticket price increases following fan backlash|
|Oviedo hopeful of new Everton contract|
|Zoff: Juventus-Napoli a Scudetto match|
|Bolton chairman Phil Gartside dies aged 63|
|Palermo turn to Bosi after Barros Schelotto exit|
|Ben Arfa considered retirement from football during exile|
|Bilic: We paid the price for cup progress|
|Griezmann happy to stay at Atletico|
|Wales to face Sweden in final Euro 2016 warm-up|
|Varela hopeful of long United career|
|Ki: I had ice on my face for two days|
|Niasse settling in well, could face West Brom - Martinez|
|Stevens leaves Hoffenheim on health grounds and retires|
|Diaby nearing return after near 18-month lay-off|
|Nasri would love to finish career at Manchester City|
|Captain Howedes extends Schalke stay|
|M´Vila keen to stay if Sunderland survive|
|Johnson admits child sex and grooming charges|
|Amazing Mahrez is one of Premier League´s best - Ulloa|
|Ronaldo, Messi rivalry good for football - Zidane|
|Barros Schelotto leaves Palermo|
|Age is just a number - Ilori defends Klopp´s team selection|
|Messi, Suarez and Neymar rested for Copa second leg|
|Madrid can dream of trophies under Zidane - Raul|
|Ancelotti: Italy job is a decade away|
|Reus will become a monster, says Dortmund boss Tuchel|
|Young Tottenham stars don´t know their limits - Lloris|
|Niang happy at Milan despite Leicester interest|
|Ticket price rise means more tourist fans, warns football supporters chairman|
|Ogbonna revels in first West Ham goal|
|Copa Libertadores Review: Huracan, River Plate advance to group stages|
|Klopp backs Benteke to rediscover goalscoring form|
|Turan will not leave Barca for China - agent|
|Beating Chelsea more difficult without Mourinho - Motta|
|Tuchel praises Dortmund for ´perfect game´|
|Klopp rues Liverpool wastefulness in FA Cup loss|
|Allegri: Chelsea rumours unfounded|
|Bilic feels weight of history after Liverpool win|
|Coupe de France Review: Second tier Sochaux stun Ligue 1 Monaco|
|West Ham 2 Liverpool 1 (aet): Ogbonna sinks Klopp´s men in cup thriller|
|Football League Review: Rhodes rescues a point to send Boro top|
|Stuttgart 1 Borussia Dortmund 3: Aubameyang helps Tuchel´s men into last four|
|Kyle Allen blames chaotic Texas A&M culture on Johnny Manziel era|
|Dortmund fans stage protest against ticket prices for Stuttgart game|
|Bayer Leverkusen 1 Werder Bremen 3: 10-man hosts dumped out|
|Ferdinand fears title wilderness for United|
|Carvalho lands new Sporting deal with €45m buy-out clause|
|Ben Arfa out for at least four weeks with hamstring injury|
|Neville´s Valencia woes welcomed by Crespo|
|Ozil key to Arsenal´s title hopes - Rosicky|
|Zika threat could keep Solo from Rio Olympics|
|Blanc pleased to have solved David Luiz matter|
|Atletico midfielder Partey suffers thigh strain|
|Dickov: Leicester title run built to last|
|Guardiola not a menace for our players, says Luis Enrique|
|Mexico v Senegal: Osorio believes in youngsters|
|Celta Vigo v Sevilla: Krohn-Dehli not taking Copa del Rey final for granted|
|Madrid confirm Marcelo shoulder dislocation|
|Injury rules Chiellini out of crucial Juve games|
|Oblak extends Atletico deal|
|Blanc hints PSG could move for Ben Arfa|
|Luis Enrique urges Neymar to cope with off-field distractions|
|Carrick: Manchester United not throwing in towel|
|Neville determined to turn things around at Valencia|
|Guardiola hails Lewandowski professionalism amid Real Madrid and PSG rumours|
|Guardiola wary of ´aggressive´ Bochum|
|Premier League reveals new logo|
|West Ham open Payet contract talks|
|I could leave Barcelona for Guardiola, says Busquets|
|Giggs can be Manchester United´s Guardiola - Robson|
|Zidane has everything to become a great coach - Ancelotti|
|Carragher: Liverpool got it wrong on ticket prices|
|Neymar will be at Barcelona for years, claims director|
|Eder talks up Inter´s Scudetto chances|
|Larsson: Watching Barca is like playing FIFA|
|City recruit Wilkinson hoping to debut in Melbourne derby|
|Allegri will join Chelsea, says former coach|
|Zanetti: No need to compare Maradona and Messi|
|Vardy: I never expected Leicester to top Premier League|
|Capello: Ronaldo has at least three years at the top|
|Klopp hoping for Sturridge revival|
|Bilic wants new contract to keep Payet at West Ham|
|Shelvey can be as good as Cabaye - Sissoko|