Bayern Munich may be reeling when they host Hamburg on Saturday after suffering just their third defeat of the year in midweek.
Manchester City came away from the Allianz Arena on Tuesday with all three points in the sides' final UEFA Champions League Group D clash, but the 3-2 scoreline was not enough to knock the Bavarians off top spot in the pool.
The loss will have been doubly galling for Pep Guardiola, having seen his side race into a two-goal lead in just 12 minutes.
Heading into the game, Bayern had won their previous 10 Champions League matches - a tournament record - and secured victories in each of their 19 fixtures at the Allianz.
They are 40 unbeaten in the Bundesliga, and had lost just twice previously in 2013 - to Arsenal in the Champions League in March and Borussia Dortmund in the DFL-Supercup in July.
And Guardiola's side will take confidence from their recent meetings with Hamburg having won the last three - including last term's 9-2 mauling in the corresponding fixture.
Attacker Thomas Muller believes the Manchester City defeat proved Bayern are not invincible - but challenged his colleagues to use it to inspire them to get back to winning was at the weekend.
"The normal human in all of us came to the surface," the Germany international said.
"We were too casual. We made a great start but let them back into it. We need to regain our utter desire to win."
Hamburg have not beaten Bayern away from home since April 2007, and their recent form has been patchy with three defeats in their last six outings.
Former Netherlands coach Bert van Marwijk has overseen four wins from his 10 games in charge since replacing Thorsten Fink in September - only lifting the club from 15th to 13th in the process.
Despite their stagnating progress, former Bayern full-back Marcell Jansen is not prepared to head to Bavaria with damage limitation in mind.
He told Hamburg's official website: "Bayern follow a clear concept and will do the same against us. We all have to play to our limit and everyone in the team must defend well.
"As a player you have to believe in your chance, otherwise there is no point in going there. That is how we will be approaching the game."
First-choice goalkeeper Rene Adler is a doubt having struggled with an ankle injury in the week, while Ivo Ilicevic has also been missing due to personal reasons.
Captain Rafael van der Vaart returned to training on Tuesday, however, after recovering from an ankle injury and off-field issues.
Bayern will be without long-term absentees Arjen Robben, Holger Badstuber (both knee) and Bastian Schweinsteiger (ankle), but have been boosted by recent returns of Xherdan Shaqiri and Claudio Pizarro.
|5||D. Van Buyten|
for M. Götze 64'
for T. Müller 78'
for T. Kroos 82'
|Martino: Barca must ride momentum|
|Liga MX Preview: Cruz Azul seek form reversal, Toluca in tow|
|Costa Rica Primera Division Wrap: Herediano stumble sends Deportivo Saprissa top|
|CONCACAF Champions League Wrap: Joy for MLS clubs|
|Copa Libertadores Wrap: Nacional Asuncion rise late, Botafogo beaten|
|J.League Preview: Kashima Antlers, Sagan Tosu in top-two tussle|
|Rooney wants United armband|
|Cousillas waves away Aguero fears|
|Cousillas waves away Aguero fears|
|Messi: Barca progress never in doubt|
|Hyypia proud of defeated Leverkusen|
|Kompany: City´s time will come|
|Blanc unhappy with sluggish PSG start|
|SPL Wrap: Prolific May ends United run, Hibernian held|
|Football League Wrap: Wigan Athletic, Sheffield United avoid FA Cup hangovers|
|UEFA Champions League: Barcelona 2 Manchester City 1 (4-1 agg)|
|Rangers lift League One title|
|UEFA Champions League: Paris Saint-Germain 2 Bayer Leverkusen 1 (6-1 agg)|
|AFC Champions League Wrap: ´Lacklustre´ Guangzhou held, Ulsan win again|
|Montella takes heart from Juve defeat|
|La Liga Preview: Vallecano meet Almeria in crunch relegation clash, Valladolid visit Sevilla|
|Eredivisie Preview: In-form PSV out to dent Vitesse´s title hopes|
|Ligue 1 Preview: Evian host Valenciennes in crucial relegation clash|
|Falcao can make World Cup claims surgeon|
|Ronaldo mentoring Jese, says Pepe|
|UEFA investigate Bayern banners|
|Good hopeful over World Cup prospects|
|Lamela could return this season, claims Sherwood|
|Vermaelen unsure over Arsenal future|
|Cambiasso vows to play on despite uncertain Inter future|
|Castro: No favourites in Porto, Napoli tie|
|Sunderland hire Congerton as sporting director|
|Southampton appoint Krueger as chairman|
|Conte could rotate for Europa League|
|Labadie given 10-match ´biting´ ban|
|Rodgers has restored fear factor, says Fowler|
|Napoli can climb to second, says Reina|
|Newcastle should sack Pardew, say fan group|
|Monk pleased with Swansea performance levels|
|Hernanes backs Inter for top four|
|Cellino ´humiliated´ by Leeds saga|
|Sunderland need Fletcher, insists Poyet|
|Robben hits out at Wenger|
|Monchengladbach extend Favre contract|
|Returning Lucas seeking World Cup berth|
|Abbiati: Milan going in the wrong direction|
|West Brom suffer Brunt injury blow|
|Simeone warning inspired convincing win, says Filipe Luis|
|Agbonlahor eyeing 40-point mark|
|Beckenbauer concerned by Barca-esque Bayern|
|Rooney keen to captain club and country|
|Copa Libertadores Wrap: Bocanegra´s late show clinches draw for Atletico Nacional|
|CONCACAF Champions League: San Jose Earthquakes 1 Toluca 1|
|Urawa Reds apologise for racist banner|
|MLS Preview: Colorado to open campaign at Red Bulls|
|A-League Preview: Premier´s Plate within reach for Brisbane|
|Bayern Munich question Arsenal´s tactics|
|Bundesliga Preview: Struggling Leverkusen face biggest test|
|League Two Wrap: Torquay shock Rochdale, Chesterfield held|
|League One Wrap: Wolves break club record, Brentford and Orient successful|
|Milan were lacking psychologically, says Seedorf|
|Ozil blow for Arsenal|
|Simeone salutes second-half display|
|Championship Wrap: Reading stun Leeds, Blackpool end barren streak|
|UEFA Champions League: Bayern Munich 1 Arsenal 1 (3-1 agg)|
|UEFA Champions League: Atletico Madrid 4 Milan 1 (5-1 agg)|
|AFC Champions League Wrap: Mariners overcome Sanfrecce, Seoul held|
|Cousillas: City can stun Barca|
|UEFA Europa League Preview: Sevilla v Real Betis|
|Charlton appoint Riga|
|New deal for Heimeroth|
|FA reject Walters appeal|
|Mertens tipped for starring role|
|Aluko getting back to his best|
|UEFA Europa League Preview: Lyon v Viktoria Plzen|
|Grosso takes control of Juve´s youth team|
|Blanc: PSG still playing Euro catch-up|
|Kaboul ban overturned|
|Pardew hit with seven-game ban|
|McCann blow for Wigan|
|Cabaye has no regrets over PSG move|
|Martinez taking no risks with Jagielka|
|I turned down Juve in 2012 - Robben|
|Lambert wants more from Tonev|
|Wanchope: City can beat Barcelona|
|Wanchope: City can beat Barcelona|
|UEFA Europa League Preview: Tottenham v Benfica|
|Remy hungry for World Cup place|
|Martino: We have not been consistent|
|UEFA Europa League Preview: Ludogorets v Valencia|
|Inter unlikely to make moves for Dzeko, Torres|
|American firm acquire United shares|
|Callejon predicting strong Napoli era|
|UEFA Europa League Preview: Juventus v Fiorentina|
|Eto´o hints at Chelsea stay|
|Hughton pleased with Bassong performances|
|Barca treble still on the cards - Alexis|
|Monk: Michu close to Swansea return|
|Solskjaer hoping to inspire Cardiff strikers|
|Toprak: Restoring pride is important|
|UEFA Europa League Preview: AZ v Anzhi|
|Charlton sack Powell after FA Cup exit|
|UEFA Europa League Preview: Basel v Red Bull Salzburg|
|Move on from Diouf blow - Dufner|
|Fonte backs Rodriguez for World Cup|
|Stoke fear extended Huth absence|
|Anichebe calls for West Brom spirit|
|Courtois rubbishes Real rumours|
|Zenit thank sacked Spalletti|
|Manchester City positive ahead of Barcelona trip|
|Martinez hopes for Deulofeu stay|
|Kroos undecided on future|
|CONCACAF Champions League: Alajuelense 0 Arabe Unido 0|
|Argentina Primera Division Wrap: Velez Sarsfield close in on top|
|Paraguay Division Profesional Wrap: Nacional Asuncion into second|
|De Boer planning Ajax stay|
|UEFA Europa League Preview: Porto v Napoli|