Borussia Dortmund coach Jurgen Klopp was crestfallen following further injuries to midfielders Sven Bender and Nuri Sahin on Saturday.
Both players were sent to hospital during Bayer Leverkusen's 1-0 win at Signal-Iduna Park on Saturday, which was decided by Son Heung-Min's first-half goal.
The game was a feisty affair, with Leverkusen's Emir Spahic and Dortmund's Sokratis Papastathopoulos sent off, and both Bender and Sahin were forced off the field after tackles from their opponents.
Klopp's side have had a particularly tough time with injuries recently, with centre-backs Neven Subotic (knee) and Mats Hummels (ankle) both long-term absentees.
Defenders Lukasz Piszczek and Marcel Schmelzer have also been absent, although the former did feature off the bench against Leverkusen.
And Klopp revealed that both Sahin and Bender were in extreme pain and were highly unlikely to feature against Marseille in the UEFA Champions League on Wednesday.
"Today is Saturday and while miracles do happen, they just haven't happened for us recently," Klopp said.
"This is not an easy phase for us. Given that two of our players are injured, possibly gravely so, it will make our next few games tricky."
Dortmund's fourth Bundesliga defeat of the season leaves them in third, only goal difference behind Borussia Monchengladbach.
They are already six points behind the second-placed Bayer Leverkusen, and 10 adrift of runway leaders Bayern Munich.
|Kenya 0 Ethiopia 0 (agg 0-2): Hosts sent out of CHAN qualifiers after second penalty miss|
|Dortmund put 17 past Olympians, Bremen hand out thrashing|
|Dinamo Zagreb confirm arrests of coach and club president|
|I didn´t know who Wimbledon guest Klopp was - Brown|
|LeBron James backs Liverpool captain Henderson for FIFA 16 cover.|
|Ramos: I am not negotiating with anyone|
|Valencia complete Mina swoop|
|United States v Japan: US seek final redemption|
|Hanousek consigns Celtic to defeat|
|Roma confirm Dzeko interest|
|Arsenal forward Podolski completes Galatasaray switch|
|Warm Dortmund welcome delights Tuchel|
|Silva vows to fight for Madrid place|
|Mancini hints at Shaqiri and Santon departures|
|Bojan raring to go after return from injury|
|Babel backs Firmino to shine at Liverpool|
|Falcao must wait to impress, warns Chelsea favourite|
|Bartomeu: Deal in place for Turan|
|Parejo re-signs with Valencia|
|MLS Review: Sounders return to winning ways|
|Klinsmann unhappy with USA performance|
|High hopes for Paraguay - Diaz|
|Gareca: More to come from Peru|
|Gerrard had European offers|
|Argentina out to spoil Chile´s party - Martino|
|Sampaoli: Chile won´t change style|
|Di Maria will come good at United - Rojo|
|Peru 2 Paraguay 0: Gareca´s men finish third at Copa|
|United States 4 Guatemala 0: Klinsmann´s men win comfortably|
|´I’d prefer no-one to know my name´ - Bassett|
|Matthews completes Sunderland move|
|Podolski set for Galatasaray medical|
|Gundogan inspires Dortmund victory|
|Inter confirm Montoya capture|
|Murillo joins Inter, as Kuzmanovic and Obi depart|
|Falcao signing not a risk, says former Chelsea star|
|Deeney agrees new Watford deal|
|Confidence and service the key to Falcao success at Chelsea|
|No bids for ´Chelsea target´ Baba, claim Augsburg|
|Derby swoop for Ince|
|Fiorentina consider legal action over Salah ´no-show´|
|Chelsea the team to beat in the Premier League, says Neville|
|Storari exits Juve for Cagliari|
|UEFA removes FFP restrictions on Man City and PSG|
|West Brom hope for new owners within the month|
|Chelsea agree loan deal for Falcao|
|Kuyt eyes trophies on Feyenoord return|
|Chile v Argentina: History beckons ahead of Copa America final|
|Wallace extends Monaco loan|
|Mihajlovic wants to instill fear factor at Milan|
|Mignolet improving at Liverpool - Grobbelaar|
|Mumbai City name Anelka player-manager|
|Olivia the parrot predicts Japan to win Women´s World Cup|
|Lusitans coach blasts Bilic´s ´lack of respect´|
|Sakho eyes more Europa League wins|
|Gareca wants Peru to keep building|
|Chile ´no chance´ if Argentina produce their best - Diaz|
|Ocampos joins Marseille permanently|
|Europa League Review: Cloud-nine Brondby ignite opening round|