Rene Meulensteen begins his tenure as Fulham head coach with a difficult home encounter against Tottenham on Wednesday.
The 49-year-old was installed as head coach at Craven Cottage on November 13, but was handed full control of first-team affairs after Fulham parted company with fellow Dutchman Martin Jol on Sunday.
Jol - who also had a spell as Tottenham boss - paid the price for a poor start to the Premier League season, including losing their last five top-flight fixtures, with the club languishing in 18th place.
His last game in charge proved to be a 3-0 defeat at West Ham on Saturday, as second-half goals from Mohamed Diame, Carlton Cole and Joe Cole secured the points for Sam Allardyce's men.
Ahead of his debut, Meulensteen - who served as first-team coach under Alex Ferguson at Manchester United - said he would use his experience to guide Fulham to safety, with the club looking to move away from the relegation zone.
Speaking to Sky Sports, he said: "I know what is required at the top end of the Premier League. This is a different challenge with different pressure. This is making sure you realise the need to keep three teams below you."
Striker Hugo Rodallega (groin) and Matthew Briggs (hernia) remain missing for Fulham, while Dimitar Berbatov (illness) and Brede Hangeland (leg) remain doubtful.
Tottenham have endured a frustrating start to the campaign, with a lack of goals accounting for their indifferent performances so far.
The White Hart Lane outfit have scored just 11 times in the 13 Premier League matches this campaign, with only Sunderland and Crystal Palace notching on fewer occasions.
But Andre Villas-Boas will be pleased with a spirited 2-2 performance at home to Manchester United on Sunday, a result that quickly eradicated the memory of a 6-0 hammering at the hands of Manchester City on November 24.
Tottenham occupy ninth position in the league standings, but are just three points adrift of Liverpool in fourth.
They will be looking for revenge, having lost 1-0 to Fulham at White Hart Lane the last time the sides met in the Premier League in March, with a Berbatov strike settling the game on that occasion.
Christian Eriksen and Danny Rose are both absent with ankle injuries for Tottenham, while Emmanuel Adebayor is doubtful with a groin injury.
|Coach: R. Meulensteen|
for G. Karagounis 62'
for A. Kačaniklić 85'
for S. Parker 87'
|Benitez denies Callejon spat|
|Brownhill stunner downs Burnley|
|Sunderland edge out Recreativo|
|Barton and Hoilett earn QPR draw|
|UEFA Champions League Review: Lafata treble puts Sparta in command, Slovan beat Sheriff|
|Gomis opens Swansea account at Exeter|
|Schneiderlin hints at Southampton discontent|
|Scolari makes Gremio return|
|Bojan strike in vain as Schalke beat Stoke|
|Tevez to miss friendly amid kidnap reports|
|Porto sign Jose Angel from Roma|
|UEFA Europa League Preview: Trencin v Hull City|
|Liverpool land Origi|
|UEFA Europa League Preview: Torino return to Europe after 20-year absence|
|Rodriguez and Schneiderlin not for sale, say Southampton|
|Rakitic: Not all about front three|
|Barkley pens new Everton deal|
|Guardiola relishing Chivas friendly|
|Drogba targets Premier League glory|
|Hull make Maguire and Robertson double swoop|
|Perisic blow for Wolfsburg|
|Ibrahimovic scores hat-trick as PSG hammer Kitchee|
|Al-Hilal coach sacked over referee row|
|La Liga boss wants cream of the crop|
|Valencia granted work permit, completes West Ham move|
|Atletico complete deal for Griezmann|
|Reus focused on fitness battle despite ´major European interest´|
|Barcelona announce club-record revenue|
|Bony could be sold for right price, says Jenkins|
|Confidence key for Newcastle, says Taylor|
|Saivet out for four weeks with knee injury|
|Genk part company with Ferrera after just one game of season|
|Gold clarifies Twitter gaffe|
|Vidic adapting to different style at Inter|
|Toulouse bring in Matheus|
|Butragueno backs Rodriguez to cope with pressure|
|Benteke aiming to come back stronger|
|Valdez joins Frankfurt|
|Jovetic ready to shine|
|Simeone hails Griezmann qualities|
|Monk unsure over De Guzman future|
|Benitez: Michu will take time to adjust|
|Diaby confident of staying fit|
|Shaw not fit enough, says Van Gaal|
|MLS Preview: RSL look for attacking spark|
|Monk slaps ´astronomical´ price on Bony´s head|
|Australian clubs looking at Ronaldinho|
|Sinclair enjoying ´one of the best pre-seasons´|
|Spiranovic surgery a success|
|Seattle Sounders 0 Los Angeles Galaxy 3: First-half blitz fires Californians to victory|
|Lemina thrilled with Bielsa effect|
|Bayern´s Green chomping at the bit|
|Palace complete US tour with easy win|
|Carragher: Liverpool didn´t want me|
|Simeone: Atleti´s La Liga triumph was no fluke|
|Sturridge: ´I´ll step up´|
|Van Gaal: Formation gives United flexibility|
|Mathieu insists age is no barrier|
|Martinez the deal sealer, says Besic|
|Coaches embrace blockbuster Serie A start|
|Ronaldinho to leave Atletico Mineiro|
|Lorient capture Ayew|
|Celtic loan Berget, sell Watt|
|Pires signs up for Indian Super League|
|Allegri set for early San Siro reunion in maiden Juve campaign|
|Bakayoko makes Monaco move|
|Bakayoko makes Monaco move|
|Lens granted Ligue 1 place|
|UEFA Champions League Preview: Red-hot Salzburg face Qarabag|
|Parma bring in Cassani from Fiorentina|
|De Vrij set for Lazio|
|BREAKING NEWS: Everton complete Besic signing|
|Kongolo pens Feyenoord extension|
|Redknapp confirms Granero exit|
|Advocaat confirmed as Serbia coach|
|CSL Preview: Henan aim to escape drop zone, Liaoning host Guangzhou RandF|
|Arribas makes Sevilla switch|
|Chambers joins Arsenal|
|Ospina buoyed by Arsenal recruitment|
|Liverpool´s loss is our gain, says Redknapp on Remy|
|Ferdinand: I would still be at United with Giggs in charge|
|Pepe targets Super Cup glory|
|Martinez prioritising striker signing|
|Perez not looking to leave Benfica|
|Klopp itching to work with full Dortmund squad|
|Mourinho: It feels like Drogba never left|
|FIFA asks for FIGC review into alleged racist remark|
|Hull to review Maguire deal|
|Wenger prepared to gamble on Chambers|
|Atletico agree Griezmann deal|
|Irvine planning further striker addition|
|Campbell: Black professionals scared to talk about racism|
|Mata backs Herrera to star in Premier League|
|Injured Rafael returning to Manchester|
|Schmidt demands more from Leverkusen|
|Copa Libertadores Preview: Defensor Sporting banking on home record|
|Remy´s Liverpool move off, confirms Rodgers|
|Inzaghi demands nastiness from Milan|
|MLS Review: Timbers triumph in Montreal, Dallas thwart Vancouver|
|Jovetic ready to lead City line - Pellegrini|
|Lewandowski impresses Ribery, Alaba|
|Colombian Primera A Review: Three clubs remain perfect, Atletico Nacional get off the mark|
|Rodgers: ´We can score goals´ without Suarez|
|Chilean Primera Division Review: Canales brace powers Universidad Chile|
|Atletico Madrid need penalties to edge past Earthquakes|
|Liga MX Review: Monterrey, America stay perfect|
|Paraguayan Primera Division Review: Capiata set pace|
|Brazilian Serie A Review: Cruzeiro win again, Kaka scores|
|Sterling goal sees Liverpool past Olympiacos|
|Peruvian Primera Division Review: Los Caimanes notch maiden win, Inti Gas claim top spot|
|CAF Champions League Review: Zamalek held, Vita Club leave it late|
|Jovetic at the double as Manchester City thrash Milan|