Leaders Leyton Orient travel to third-placed Colchester United on Saturday as they aim to maintain their 100 per cent record in League One.
Russell Slade's side have won all four of their league games and boast an in-form striker in the shape of David Mooney, who has scored four goals so far this season.
Colchester are also in good form but, after two wins in the opening two games, have been held in their last two matches.
However, history suggests that John Ward's men will get a positive result against Orient, as the Londoners have not won a league fixture at Colchester in 19 attempts and lost both matches against them last season.
Like Orient, second-placed Peterborough United are also aiming to record a fifth straight win when they welcome Crawley Town to London Road and confidence will be high after thrashing Reading 6-0 in the League Cup second round on Tuesday.
The two sides have never met before, but Darren Ferguson will be confident given his side's eye for goal this season, as Peterborough have scored 12 in their opening four league matches.
After last season's play-off heartbreak, Brentford have begun the new campaign well and find themselves in fourth place and unbeaten.
Uwe Rosler's men face a long trip north to Carlisle United, who sit second bottom in the league.
They managed to pick up their first point of the season against Colchester, but have not won at home since the two sides last met in March and have conceded nine goals in their previous two league home fixtures.
Coventry City - who began the season on minus 10 points - could wipe out that deficit with victory over Shrewsbury Town.
Steven Pressley's side are top scorers in the division so far with 15 goals in their four games - with Leon Clarke and Callum Wilson looking sharp in front of goal.
Following their promotion last season, Bradford City have adjusted to life in League One well, as they are yet to be beaten and will be aiming to extend that run away to Stevenage.
Striker Nakhi Wells will provide the main threat to Graham Westley's side - the Bermuda international leads the way in the division's scoring charts with five goals.
Wolves have won three games in a row since their opening-day draw with Preston North End, and they head to newly promoted Port Vale.
The two sides have not met since 2000, when Wolves won 1-0 at Vale Park thanks to a Carl Robinson strike.
Sheffield United's start to the season has taken a turn for the worse since their opening-day victory over Notts County, as they have not won since and lost their Yorkshire derby against Bradford last time out.
Chris Morgan will hope his side can get back to winning ways when they entertain Karl Robinson's MK Dons at Bramall Lane.
Elsewhere, Notts County and Tranmere Rovers all go in search of their first win against Rotherham United and Oldham Athletic respectively. Both County and Tranmere produced spirited displays in the League Cup in midweek - Tranmere beat Bolton Wanderers on penalties and County hauled themselves level having been 2-0 down against Liverpool before losing 4-2 at Anfield.
Two of the bottom four go head-to-head at Priestfield as Bristol City travel to Gillingham in a repeat of their League Cup first-round tie earlier in the month - a game City won 2-0. City also defeated Premier League side Crystal Palace in the second round on Tuesday.
Meanwhile, Preston travel to Walsall and Swindon Town welcome Crewe Alexandra to the County Ground fresh from their League Cup victory at QPR that set up a third-round home clash against Chelsea.
|Coach: J. Dunne|
|Coleman sees shades of Charles in Bale winner|
|Conte only concerned about Italy winning|
|Mauritania v South Africa: SAFA to investigate Masilela no-show|
|AFC World Cup Qualifying Review: Qatar hit 15 in Bhutan rout|
|Belgium 3 Bosnia-Herzegovina 1: De Bruyne shines in straightforward victory|
|Cyprus 0 Wales 1: Bale winner takes Wales one step closer|
|Netherlands 0 Iceland 1: Sigurdsson winner caps difficult first game for Blind|
|Italy 1 Malta 0: Pelle spares wasteful Azzurri|
|Balotelli stars in Milan friendly win|
|Bhutan thrashed 15-0 by Qatar in qualifier|
|Rwanda v Ghana: Gyan doubt gives hosts hope|
|Tanzania v Nigeria: Enyeama out of AFCON qualifier|
|Valdes and Berahino included in Premier League squads|
|Costa Rica v Brazil: Dunga´s men return after Copa disappointment|
|Spain v Slovakia: Azpilicueta eyeing important revenge|
|Adebayor left out of Tottenham squad list for league and Europe|
|San Marino v England: Place in history books beckons for Rooney|
|Germany can cope with Reus absence - Low|
|Bayern offer aid to refugees in ´training camp´|
|BREAKING NEWS: Welbeck ruled out for months after knee surgery|
|South Korea 8 Laos 0: Son leads the way in rout|
|Australia 5 Bangladesh 0: Socceroos surge to emphatic win|
|Japan 3 Cambodia 0: Hosts pick up first qualifying win|
|Rudiger aiming to nail down Euros spot after Roma move|
|Melo happy to join Inter at last|
|Hernandez thanks Ferguson after United departure|
|Chung: AFC has compromised FIFA election|
|Wales the new best of British|
|Reus out of Germany qualifiers|
|Chile v Paraguay: Vidal missing for Copa champions|
|Ghedin: Anything is possible for Malta|
|Pogba will be worth €100m - Marotta|
|England can win Euro 2016 - Hodgson tells players|
|Conte unsure over Balotelli future|
|Portugal - France Preview: Deschamps aiming to correct mistakes|
|Martial never the same again - Mangala|
|Copa del Rey Review: Racing fall at the first|
|Shelvey dismisses talk of England snub|
|Galatasaray unable to play Grosskreutz|
|Faroe Islands v Northern Ireland: O´Neill preaches patience ahead of Euro double-header|
|Levy slams ´wholly inappropriate´ West Brom after Berahino chase|
|Panama v Uruguay: Visitors without Suarez and Cavani|
|Captaincy won´t change me - Robben|
|Liverpool sign Brazilian youngster Allan|
|PFA expects swift Berahino resolution|
|Argentina v Bolivia: Mascherano backs ´very special´ Messi|
|´I do not know if I´m worth €80million´ - Martial shocked at price-tag|
|Afellay suspension reduced|
|Noble red card rescinded|
|Portugal v France: Deschamps aiming to correct mistakes|
|Bahebeck given the all clear|
|Germany v Poland: Muller out to settle the score|
|Gibraltar v Republic of Ireland: Keane counting on McCarthy and Walters|
|Georgia v Scotland: Tbilisi trip has must-win feel for Robertson|
|Juve still the team to beat - Hernanes|
|De Gea will remain professional, says team-mate Mata|
|Berahino given extra time off following strike tweet|
|´No excuses´ as Costa seeks to kick-start season|
|I´m not like Messi or Ronaldo – Hazard|
|United States v Peru: Klinsmann out to ´prove a point´|
|Martinez unsure when Cleverley will return|
|France set for Russia friendly ahead of Euros|
|Former Manchester United forward Berbatov joins PAOK|
|De Gea must play to earn Euro 2016 spot – Del Bosque|
|Cahill thrilled to lead Socceroos|
|Wijnaldum urges patience with new-look Newcastle|
|Reid praises Stones´ professionalism|
|Mexico v Trinidad and Tobago: Islanders hoping to build on Gold Cup display|
|Choosing Brazil over Spain was easiest decision, says Rafinha|
|Galliani hails ´changed´ Balotelli|
|OFC World Cup Qualifying Review: American Samoa notch second competitive win|
|Canada v Belize: Hosts look to stay calm|
|Carragher surprised by ´big´ Martial price|
|No pressure on Rodgers - Rush|
|No Benzema, no Cavani - Arsenal ´can´t compete´ says Sol Campbell|
|FFA muzzle Postecoglou after pay dispute criticism|
|Celtic complete Simunovic signing|
|Joaquin: I´m as happy as a little boy|
|Navas given time off by Costa Rica|
|Martial unfazed by prospect of United pressure|
|Ramos urges De Gea to overcome transfer woe|