Gerardo Martino is looking to preserve Barcelona's 100 per cent start to the La Liga season when his side travel to Valencia on Sunday.
The reigning champions have started the new campaign with two wins from two games thanks to their 7-0 drubbing of Levante and a 1-0 success over Malaga.
But their season continues with a tricky test at Mestalla against Miroslav Dukic's side.
Martino is boosted by the return to fitness of Argentina international Lionel Messi after his star player's recent trouble with a thigh injury.
The 26-year-old did not feature in the victory over Malaga, but started in Wednesday's Supercopa de Espana second leg against Atletico Madrid, missing an 89th-minute penalty as Barca won on away goals.
Valencia harbour ambitions of breaking back into the UEFA Champions League places after finishing fifth in 2012-13, but they have had a mixed start.
Dukic's men began with a solid 1-0 triumph over Malaga through Ricardo Costa's second-half strike, but were well beaten in a 3-1 loss away to Espanyol last time out.
Carlo Ancelotti's Real Madrid host Athletic Bilbao at the Bernabeu, having also won their opening two games.
They came from behind to beat Real Betis 2-1 in the Italian's first game in charge, and followed that by beating Granada 1-0 thanks to a Karim Benzema effort.
Midfielder Mesut Ozil is delighted with the club's winning start, but conceded their performances must get better if they are to regain the La Liga title from Barcelona.
"We are happy we have won both games (and taken) six points," he said.
"We know we have to play better football. There's still room for improvement and we will do that in the future."
Two sides who finished in the Champions League positions last season face off, when Real Sociedad host Atletico Madrid at the Estadio Municipal de Anoeta.
Sociedad booked their place in the Champions League group stages with a 4-0 aggregate win over Lyon, sealed courtesy of a 2-0 victory in the second leg on Wednesday night thanks to a Carlos Vela brace.
Diego Simeone's Atletico sit second in the table following a 3-1 success away to Sevilla and a 5-0 rout of Rayo Vallecano last Sunday.
Elsewhere on Saturday, Espanyol and Sevilla have home fixtures against Real Betis and Malaga respectively, with the two away sides yet to register a point this season.
Osasuna prop up the table, and will look for their first points of the campaign when they welcome Villarreal to the Estadio El Sadar. Jose Luis Medilibar's team have been on the wrong end of defeats to Granada and Athletic Bilbao in their opening matches.
Real Valladolid are also winless, and will look to buck that trend when they host Getafe, while Celta Vigo and Granada go head-to-head at the Estadio de Balaidos.
Other matches see Almeria welcome Elche and Levante travel to Rayo Vallecano on Friday.
|9||Hélder Postiga||45' 45+3'|
|Coach: M. Đukić|
for É. Banega 68'
for Canales 69'
for Míchel 82'
|Benitez happy with response to Barcelona thrashing|
|Marchisio satisfied by battling win over City|
|Hareide quiet on Malmo future after heavy PSG defeat|
|Van Gaal aware of Wolfsburg challenge|
|Griezmann focused on winning Group C after Gala win|
|Real Madrid relaxed too much, admits Carvajal|
|Toure laments missed chances as Juve sink City|
|Europa League is Gala´s new goal - Muslera|
|Rooney bullish on Champions League chances|
|Borussia Monchengladbach 4 Sevilla 2: Stindl double sends Liga side out|
|Malmo 0 Paris Saint-Germain 5: Ibrahimovic on target as Blanc´s side cruise through|
|Shakhtar Donetsk 3 Real Madrid 4: Ronaldo wins the group despite late comeback|
|Manchester United 0 PSV 0: Stalemate leaves Van Gaal´s men facing tricky final game|
|Juventus 1 Manchester City 0: Mandzukic seals qualification as Juve leapfrog City|
|Atletico Madrid 2 Galatasaray 0: Griezmann double sends Simeone´s men through|
|Slutsky reflects on "humiliating" defeat|
|´We worked hard for that´ - Schafer revels in Wolfsburg win|
|Dier wary of Qarabag threat|
|Celtic captain Brown out for up to three months with knee injury|
|Supporters´ absence will be tough in Belgium - Sarri|
|Watzke dismisses talk of Hummels rift|
|Teams in Europe need Premier League fixture help - Pochettino|
|CSKA Moscow 0 Wolfsburg 2: Schurrle eliminates Slutsky´s side|
|Serie A not priority for Fiorentina - Sousa|
|Ibrahimovic still cool on Guardiola as he ponders future|
|Tuchel demands Dortmund response|
|Jimenez relieved to end goal drought as Benfica snatch draw|
|Fleetwood´s Ball has Messi and Tevez in his sights|
|Isco handed two-match ban after Clasico dismissal|
|Astana 2 Benfica 2: Jimenez double seals comeback|
|Valdes ´fighting to be free´ from Manchester United|
|Lovren: It´s a great pleasure to play under Klopp|
|Sturridge set for Liverpool comeback|
|Drogba backs Cech to lead Arsenal to title|
|Mourinho explains Hazard substitution against Maccabi|
|Klopp insists Liverpool have no Anfield problem|
|Neuer has taken the game to ´a new level´ - Kahn|
|Klopp is ready to replace Mignolet, claims Grobbelaar|
|Barcelona confirm Sergi Roberto ankle injury|
|Australia, Postecoglou nominated for AFC awards|
|Dortmund rest Reus and Aubameyang for Krasnodar clash|
|Dynamo Kiev receive UEFA fine, stadium closure|
|Boyd against USA match proposal|
|Javi Martinez wants Bayern renewal|
|Barcelona certain Neymar will renew contract|
|Sanchez impossible to defend against - Koscielny|
|Aguero can be Manchester City´s Messi, says Buffon|
|There is something wrong between Lewandowski and Robben, claims Matthaus|
|Bayern on track for Champions League glory - Muller|
|Lovren hails ´unbelievable´ Firmino|
|Cech: Arsenal have everything in own hands|
|Van Nistelrooy believes Depay not ready to make the difference at Manchester United|
|´I like to spend money´ - Wenger|
|´It was beautiful to watch´ - Szczesny after Roma´s 6-1 loss to Barca|
|Simeone: Atletico won´t settle for draw|
|City must believe they can win Champions League - Hart|
|Gerrard confirms Liverpool training return|
|Rooney told to make China move by Eriksson|
|Vanhaezebrouck: Overachieving Gent deserve to advance|
|Barca an ´unbeatable machine´ - Garcia|
|Jokanovic proud of Maccabi progress|
|Luis Enrique wants more after Barcelona hit Roma for six|
|Sevilla in talks to keep hold of Banega|
|Guardiola ´satisfied´ after Bayen brush aside Olympiacos|
|We are thinking about Arsenal now, admits Silva|
|Mourinho plays down Costa row|
|Messi: It feels good to be back for Barcelona|
|Victory will spur us on - Rebrov|
|Arsenal will go through - Dinamo boss Mamic|
|Cahill delighted with Chelsea display in Maccabi win|
|Suarez thrilled to see Messi star on return|
|Bedimo bemoans ´wasteful´ Lyon|
|Layun calls for Porto response after loss|
|Lahm praises Bayern Munich after heavy home win|
|Roma ´lucky´ to lose 6-1 at Barcelona - Maicon|
|Terry a doubt for Tottenham match - Mourinho|
|Wenger: I´ve never seen Ozil in the box so much|
|Zenit have ´moral responsibility´ to beat Gent - Villas-Boas|
|Bellerin backs Arsenal to challenge for Champions League|
|Cocu: I hope United fans don´t boo Moreno|
|Maccabi Tel Aviv 0 Chelsea 4: Mourinho´s men overwhelm 10-man hosts|
|Lyon 1 Gent 2: Stoppage-time strike puts Fournier´s side out|
|Bayern Munich 4 Olympiacos 0: First-half blitz too much for sorry Greeks|
|Porto 0 Dynamo Kiev 2: Visitors stay alive with win|
|Barcelona 6 Roma 1: Messi, Suarez run riot|
|Arsenal 3 Dinamo Zagreb 0: Sanchez stars as Gunners stay alive|
|Silva, Bony could face Southampton - Pellegrini|
|Schmidt annoyed by wasteful Leverkusen|
|Sevilla squad ready to win, insists Emery|
|Nuno: Valencia won´t fail in Mestalla ´final´|
|Celtic and Dundee discussing Stateside fixture|
|Suarez has joined Messi and Ronaldo in world´s top three - Gerrard|
|Pellegrini wants Sevilla repeat against Juventus|
|Navas has belief in Real Madrid team-mates|
|Messi starts for Barcelona in Roma clash|
|Allegri demands Champions League impact from Juve|
|Zenit 2 Valencia 0: Shatov makes it five from five for Villas-Boas´ men|
|BATE 1 Bayer Leverkusen 1: Draw sees Barcelona qualify|
|Van Persie dismisses links to Chelsea and Barcelona|
|Benitez talks up Madrid unity after Clasico humbling|
|Marchisio wary of Manchester City ´backlash´|
|´Cheap´ Mourinho has ´let himself down as a manager and a man´ - Parker|
|Blanc: Ibrahimovic not a machine|
|Qarabag v Tottenham: Rose hails Pochettino with Spurs in peak form|
|Celtic v Ajax: Rogic bullish about progression chances|
|Club Brugge-Napoli fixture to be played behind closed doors|
|Euro 2016 fan zones to go ahead|
|Ibrahimovic: I will retire if I no longer feel good enough|
|Benfica can cope without Luisao and Gaitan - Rui Vitoria|
|Van Gaal wants a winger but won´t be drawn on Robben|
|Man discharged from hospital after White Hart Lane stabbing|
|FC Krasnodar v Borussia Dortmund: Hosts eye qualification|
|Liverpool v Bordeaux: Klopp´s loving touch inspires Mignolet|
|Van Gaal confirms Rooney, Martial fit to face PSV|
|Garcia hints he could end career at Roma|
|Ibrahimovic return will be special, says Rosenberg|
|Materazzi takes swipe at Benitez|
|Schubert determined to pip Sevilla to third place|
|No Napoli fans allowed at Club Brugge Europa League match|
|Rooney, Martial resume Manchester United training|
|De Gea expects Depay to hit top form|
|Platini lawyer claims FIFA Ethics Committee seeking life ban for UEFA president|
|De Jong finding it tough to stay patient at Newcastle|
|Struggling Stuttgart fire Zorniger|
|Yaya Toure: Manchester City want quadruple|
|Manchester United always believed in me - Lingard|
|Mascherano ruled out of Roma clash|
|Barca speculation an honour - Florenzi|
|Ibrahimovic adamant PSG can win Champions League|
|Pieters open to Stoke renewal|
|Di Maria back for PSG, Pastore and Lavezzi still out|
|De Boer backs Depay to emulate Manchester United great Ronaldo|
|Neville: Manchester City should be walking Premier League|
|Arsenal would take Europa League seriously - Wenger|
|PSG to make further tribute to Paris attack victims|
|Benzema one of the world´s best, says Ancelotti|
|Mourinho: Chelsea can still win Champions League|
|Franjic talks up City´s title chances|
|Gerrard to play with Liverpool legends in Sydney|
|Europa League Preview: Celtic facing crucial clash, Liverpool poised|
|Neville: Vardy must prove form against big teams|
|Ranieri: I beat Van Gaal´s Barca three times in 10 days|
|Pochettino bemoans Tottenham´s busy fixture list|
|Hazard better as a winger - Mourinho|
|Aguero: City ready to challenge for Champions League|
|Zidane is ready for Madrid job - Ancelotti|
|Palace had no answer to defensive Sunderland - Pardew|
|Mamic hits back at Wenger|