Udinese must overcome a shock first-leg loss to Slovan Liberec if they wish to progress to the UEFA Europa League group stage on Thursday.
The Italians were stunned 3-1 at their home ground by the Czech Republic side, who are in excellent form having won 12 of their last 15 competitive matches.
Veteran striker Antonio Di Natale scored in both legs of Udinese's third-round qualifying match against Siroki Brijeg and the Serie A club will need the Italian international firing on all cylinders again if it is to overturn the deficit against Liberec.
Fellow Italian side Fiorentina will take a slender 2-1 advantage into their second leg at home against Switzerland's Grasshopper.
With two away goals in Zurich, Fiorentina will be favourites to progress but the plucky Swiss side could surprise.
English Premier League side Tottenham will take a five goal advantage into their second leg at White Hart Lane against Georgia's Dinamo Tbilisi, while Swansea City won 5-1 against Romania's Petrolul Ploiesti and should advance comfortably to the group stage.
Spanish side Sevilla will be confident of advancing to the group stage, holding a 4-1 lead over Poland's Slask Wroclaw.
The Poles nicked a shock lead in Sevilla before the home side pulled a goal back in the first half and then ran riot in the second stanza.
Sevilla's local rivals Real Betis welcome Czech Republic's Jablonec to the Estadio Benito.
Betis toiled hard for a 2-1 away win in the first leg and will be keen to bounce back against Jablonec after a 2-1 loss to Celta Vigo in La Liga on Sunday.
Stuttgart needs to overcome a 2-1 first-leg defeat in Croatia against Rijeka to advance to the group stage.
The Bundesliga club were hit by two late Rijeka goals to be 2-0 down before Vedad Ibisevic's 89th minute away goal salvaged a situation that was looking dire.
Other German representatives Eintracht Frankfurt are much more comfortable in their tie against Azerbaijan's Qarabag with two away goals in the bag before the second leg at home.
Stefan Aigner assisted both of Alex Meier's two goals in Azerbaijan in a 2-0 victory.
Dutch side AZ Alkmaar should have no issues advancing after a 3-1 first-leg win in Greece against Atromitos Athens.
The Greeks have not won any of their past six games and are expected to struggle in the second leg at the AFAS Stadion.
It is a different story for other Eredivisie team Feyenoord, who were beaten 1-0 by Kuban Krasnodar in the opening battle in Russia.
The Dutch giants snapped a four game losing streak with their 3-1 triumph over NAC Breda in their domestic league and will be hoping that form continues against the Russians.
In other second-leg ties,Russia's Rubin Kazan meet Norway's Molde having scored two away goals, France's St.Etienne must overcome a 4-3 defeat to Danish side Esbjerg and Cyproit team Apollon hold a 2-0 advantage over Ligue 1's Nice.
|11||M. Frýdek jr.|
|Coach: J. Silhavy|
for J. Šural 84'
for M. Rabusic 86'
for S. Rybalka 90'
|Jojic makes Cologne switch, Santana move falls through|
|Carrillo keen to get going at Monaco|
|Micronesia thrashed 38-0 as Fiji triumph in Olympic qualifier|
|Schalke stunned by ´machine´ Caicara|
|MLS Review: Keane shines at Gerrard´s Galaxy unveiling|
|Counter-attacking the key for Japan|
|Jimenez happy at Atletico|
|Gerrard predicts ´successful future´ with Galaxy|
|Iniesta can´t see Real selling Ramos|
|Keshi sacked as Nigeria coach|
|Three finals, three defeats for Messi, Mascherano|
|Nani close to Fenerbahce move|
|Sampaoli revels in ´unbelievable joy´|
|Bravo: Copa victory a dream|
|Martino: Argentina should have won|
|Chile 0 Argentina 0 (4-1 on penalties): Hosts end trophy drought|
|Germany 0 England 1 (after extra time): England make World Cup history|
|Kenya 0 Ethiopia 0 (agg 0-2): Hosts sent out of CHAN qualifiers after second penalty miss|
|Dortmund put 17 past Olympians, Bremen hand out thrashing|
|Dinamo Zagreb confirm arrests of coach and club president|
|I didn´t know who Wimbledon guest Klopp was - Brown|
|LeBron James backs Liverpool captain Henderson for FIFA 16 cover.|
|Ramos: I am not negotiating with anyone|
|Valencia complete Mina swoop|
|United States v Japan: US seek final redemption|
|Hanousek consigns Celtic to defeat|
|Roma confirm Dzeko interest|
|Arsenal forward Podolski completes Galatasaray switch|
|Warm Dortmund welcome delights Tuchel|
|Silva vows to fight for Madrid place|
|Mancini hints at Shaqiri and Santon departures|
|Bojan raring to go after return from injury|
|Babel backs Firmino to shine at Liverpool|
|Falcao must wait to impress, warns Chelsea favourite|
|Bartomeu: Deal in place for Turan|
|Parejo re-signs with Valencia|
|MLS Review: Sounders return to winning ways|
|Klinsmann unhappy with USA performance|
|High hopes for Paraguay - Diaz|
|Gareca: More to come from Peru|
|Gerrard had European offers|
|Argentina out to spoil Chile´s party - Martino|
|Sampaoli: Chile won´t change style|
|Di Maria will come good at United - Rojo|
|Peru 2 Paraguay 0: Gareca´s men finish third at Copa|
|United States 4 Guatemala 0: Klinsmann´s men win comfortably|
|´I’d prefer no-one to know my name´ - Bassett|
|Matthews completes Sunderland move|
|Podolski set for Galatasaray medical|
|Gundogan inspires Dortmund victory|
|Inter confirm Montoya capture|
|Murillo joins Inter, as Kuzmanovic and Obi depart|
|Falcao signing not a risk, says former Chelsea star|
|Deeney agrees new Watford deal|
|Confidence and service the key to Falcao success at Chelsea|
|No bids for ´Chelsea target´ Baba, claim Augsburg|
|Derby swoop for Ince|
|Fiorentina consider legal action over Salah ´no-show´|
|Chelsea the team to beat in the Premier League, says Neville|
|Storari exits Juve for Cagliari|
|UEFA removes FFP restrictions on Man City and PSG|
|West Brom hope for new owners within the month|
|Chelsea agree loan deal for Falcao|
|Kuyt eyes trophies on Feyenoord return|
|Chile v Argentina: History beckons ahead of Copa America final|
|Wallace extends Monaco loan|
|Mihajlovic wants to instill fear factor at Milan|
|Mignolet improving at Liverpool - Grobbelaar|
|Mumbai City name Anelka player-manager|
|Olivia the parrot predicts Japan to win Women´s World Cup|
|Lusitans coach blasts Bilic´s ´lack of respect´|
|Sakho eyes more Europa League wins|
|Gareca wants Peru to keep building|
|Chile ´no chance´ if Argentina produce their best - Diaz|
|Ocampos joins Marseille permanently|
|Europa League Review: Cloud-nine Brondby ignite opening round|