Udinese must overcome a shock first-leg loss to Slovan Liberec if they wish to progress to the UEFA Europa League group stage on Thursday.
The Italians were stunned 3-1 at their home ground by the Czech Republic side, who are in excellent form having won 12 of their last 15 competitive matches.
Veteran striker Antonio Di Natale scored in both legs of Udinese's third-round qualifying match against Siroki Brijeg and the Serie A club will need the Italian international firing on all cylinders again if it is to overturn the deficit against Liberec.
Fellow Italian side Fiorentina will take a slender 2-1 advantage into their second leg at home against Switzerland's Grasshopper.
With two away goals in Zurich, Fiorentina will be favourites to progress but the plucky Swiss side could surprise.
English Premier League side Tottenham will take a five goal advantage into their second leg at White Hart Lane against Georgia's Dinamo Tbilisi, while Swansea City won 5-1 against Romania's Petrolul Ploiesti and should advance comfortably to the group stage.
Spanish side Sevilla will be confident of advancing to the group stage, holding a 4-1 lead over Poland's Slask Wroclaw.
The Poles nicked a shock lead in Sevilla before the home side pulled a goal back in the first half and then ran riot in the second stanza.
Sevilla's local rivals Real Betis welcome Czech Republic's Jablonec to the Estadio Benito.
Betis toiled hard for a 2-1 away win in the first leg and will be keen to bounce back against Jablonec after a 2-1 loss to Celta Vigo in La Liga on Sunday.
Stuttgart needs to overcome a 2-1 first-leg defeat in Croatia against Rijeka to advance to the group stage.
The Bundesliga club were hit by two late Rijeka goals to be 2-0 down before Vedad Ibisevic's 89th minute away goal salvaged a situation that was looking dire.
Other German representatives Eintracht Frankfurt are much more comfortable in their tie against Azerbaijan's Qarabag with two away goals in the bag before the second leg at home.
Stefan Aigner assisted both of Alex Meier's two goals in Azerbaijan in a 2-0 victory.
Dutch side AZ Alkmaar should have no issues advancing after a 3-1 first-leg win in Greece against Atromitos Athens.
The Greeks have not won any of their past six games and are expected to struggle in the second leg at the AFAS Stadion.
It is a different story for other Eredivisie team Feyenoord, who were beaten 1-0 by Kuban Krasnodar in the opening battle in Russia.
The Dutch giants snapped a four game losing streak with their 3-1 triumph over NAC Breda in their domestic league and will be hoping that form continues against the Russians.
In other second-leg ties,Russia's Rubin Kazan meet Norway's Molde having scored two away goals, France's St.Etienne must overcome a 4-3 defeat to Danish side Esbjerg and Cyproit team Apollon hold a 2-0 advantage over Ligue 1's Nice.
|11||M. Frýdek jr.|
|Coach: J. Silhavy|
for J. Šural 84'
for M. Rabusic 86'
for S. Rybalka 90'
|Guardiola satisfied with Cologne victory|
|Espanyol 1 Cordoba 0: Abraham goal secures the points|
|Marseille 2 Caen 3: Hosts throw lead away yet again|
|Bayern Munich 4 Cologne 1: Champions move 11 points clear|
|Dordrecht 2 Go Ahead Eagles 1: Klaiber leaves it late|
|Luis Enrique laments English ´campaign´ over Suarez|
|Atletico Madrid v Sevilla: Champions attempt to bounce back|
|De Gea dismisses ´lies´ about Van Gaal relationship|
|Monaco v Paris Saint-Germain: Jardim wants no Champions League distractions|
|Inter v Fiorentina: Both sides on a high after Europa League success|
|Real Madrid v Villarreal: Ancelotti´s side looking to keep chasing pack at bay|
|Arsenal v Everton: Hurting Wenger calls for immediate response|
|Hull and Panathinaikos among four clubs pay FFP fines|
|Liverpool v Manchester City: Champions eye long-awaited Anfield success|
|Lucas Moura out for at least four weeks|
|Chelsea v Tottenham: Mourinho´s men channel spirit of 2005|
|Loan move to Ipswich an easy decision for Wood|
|Qatar World Cup final no later than December 18 - Blatter|
|Martinez excited by Kiev draw|
|Dynamo face disciplinary hearing after crowd trouble|
|Hughes close on signing new Stoke deal|
|Parma game called off again|
|De Boer to stay at Ajax|
|Arnesen backs Vieira as potential future City director of football|
|Mourinho has no fears over Wembley referee|
|Van Persie absent for Sunderland clash|
|Mason hoping to relive 2008 at League Cup final|
|Fiorentina and Roma to meet in Europa League|
|Inter finalise Felipe swoop|
|Poyet delighted to have ´contagious´ Cattermole back|
|Melbourne City 3 Adelaide United 1: Baharudin triggers crucial comeback|
|Chelsea can cope with Matic absence - Terry|
|Mancini: I tried to take Guarin to Galatasaray|
|Wilshere undergoes ankle procedure|
|Bruce: Most Championship clubs would struggle with FFP|
|Henry would say yes to Arsenal job|
|Mignolet backs ´devastated´ Liverpool to regroup|
|Tiote looks set to miss the rest of the season|
|Copa Libertadores Review: Osvaldo scores for Boca, Internacional win|
|Alajuelense 5 DC United 2: Costa Ricans set for semis|
|Besiktas settled score with Liverpool - Cenk|
|Montella: Hard to keep Salah|
|Martinez salutes Everton´s qualification|
|Europa League games marred by crowd trouble|
|UEFA Europa League Review: Lovren misses crucial spot kick as Liverpool crash out|
|Rodgers rues lack of Liverpool guile|
|Pochettino laments ´key´ Soldado miss|
|Everton 3 Young Boys 1 (7-2 agg): Tormentor-in-chief Lukaku on song again|
|Serie A games to start late in show of support for Parma|
|Mancini irked by mistakes despite win|
|Besiktas 1 Liverpool 0 (aet, 1-1 agg, 5-4 pens): Lovren misses decisive spot-kick|
|Chelsea agree record sponsorship deal|
|Fiorentina 2 Tottenham 0 (3-1 agg): Gomez and Salah eliminate Spurs|
|Inter 1 Celtic 0 (4-3 agg): Guarin stunner sees Mancini´s men through|
|Manchester United v Sunderland: Poyet eyeing another Old Trafford upset|
|Monk has no problem with Van Gaal|
|Borussia Dortmund v Schalke: Di Matteo buzzing ahead of derby debut|
|Poyet not prepared to risk returning duo against United|
|Sherwood seeks six wins for survival|
|Championship Preview: Neil relishing East Anglian derby|
|Newcastle United v Aston Villa: Carver praises rejuvenated visitors|
|Granada v Barcelona: Catalan giants aiming to put pressure back on Real|
|Burnley v Swansea City: Monk targets 40 points in record time|
|Stoke City v Hull City: Meyler focused on maintaining resurgence|
|West Brom v Southampton: Pulis warns of continued dogfight|
|Police identify Chelsea fans over racist chanting|
|Guardiola warns against complacency|
|West Ham v Crystal Palace: Allardyce wary of being caught on counter|
|Parma GM compares club to the Titanic|
|Alderweireld close to Southampton return|
|Dyche keen to move on from Barnes furore|
|Gutierrez in Newcastle squad for Villa clash|
|Union chief urges action over Serbia gun threat|
|Berahino doubtful for Southampton clash|
|German citizenship? Why not? - Ribery|
|League Two Preview: Bury hope winning environment rubs off, Burton host Newport|
|Klopp hoping to avoid any nasty surprises after bomb discovery|
|Blackett pens new United deal|
|Sakho to return to training|
|Flores quits Getafe for personal reasons|
|Busquets agrees new Barcelona deal|
|Martino ´could not be happy´ at Barcelona|
|Allardyce striving to develop more Nobles|
|Nani hopeful of United return|
|Unexploded bomb found near Dortmund stadium|
|Lippi leaves Evergrande for personal reasons|
|Chelsea issue cup final warning to fans|
|Ancelotti has no intention to re-sign Morata|
|Dunkin´ Donuts sorry after Liverpool fans slam alternate club crest|
|Noble signs new West Ham contract|
|Sterling hopeful of contract resolution|
|Ali renews UAE contract|
|Deportivo Saprissa 0 America 3: Visitors win with late blitz|
|Copa Libertadores Review: Pato´s streak continues|
|Chievo v Milan: Abbiati wants consistency from Inzaghi´s men|
|Valverde wants momentum ahead of ´crucial´ week|
|Deila challenges Van Dijk, Denayer|
|Serie A Preview: Roma in crucial clash with Juve, resurgent Inter at home|
|Prince Albert: I feel for Wenger|
|Jardim salutes Monaco´s game plan|
|Schmidt dreaming of UEFA Champions League quarter finals|