Udinese must overcome a shock first-leg loss to Slovan Liberec if they wish to progress to the UEFA Europa League group stage on Thursday.
The Italians were stunned 3-1 at their home ground by the Czech Republic side, who are in excellent form having won 12 of their last 15 competitive matches.
Veteran striker Antonio Di Natale scored in both legs of Udinese's third-round qualifying match against Siroki Brijeg and the Serie A club will need the Italian international firing on all cylinders again if it is to overturn the deficit against Liberec.
Fellow Italian side Fiorentina will take a slender 2-1 advantage into their second leg at home against Switzerland's Grasshopper.
With two away goals in Zurich, Fiorentina will be favourites to progress but the plucky Swiss side could surprise.
English Premier League side Tottenham will take a five goal advantage into their second leg at White Hart Lane against Georgia's Dinamo Tbilisi, while Swansea City won 5-1 against Romania's Petrolul Ploiesti and should advance comfortably to the group stage.
Spanish side Sevilla will be confident of advancing to the group stage, holding a 4-1 lead over Poland's Slask Wroclaw.
The Poles nicked a shock lead in Sevilla before the home side pulled a goal back in the first half and then ran riot in the second stanza.
Sevilla's local rivals Real Betis welcome Czech Republic's Jablonec to the Estadio Benito.
Betis toiled hard for a 2-1 away win in the first leg and will be keen to bounce back against Jablonec after a 2-1 loss to Celta Vigo in La Liga on Sunday.
Stuttgart needs to overcome a 2-1 first-leg defeat in Croatia against Rijeka to advance to the group stage.
The Bundesliga club were hit by two late Rijeka goals to be 2-0 down before Vedad Ibisevic's 89th minute away goal salvaged a situation that was looking dire.
Other German representatives Eintracht Frankfurt are much more comfortable in their tie against Azerbaijan's Qarabag with two away goals in the bag before the second leg at home.
Stefan Aigner assisted both of Alex Meier's two goals in Azerbaijan in a 2-0 victory.
Dutch side AZ Alkmaar should have no issues advancing after a 3-1 first-leg win in Greece against Atromitos Athens.
The Greeks have not won any of their past six games and are expected to struggle in the second leg at the AFAS Stadion.
It is a different story for other Eredivisie team Feyenoord, who were beaten 1-0 by Kuban Krasnodar in the opening battle in Russia.
The Dutch giants snapped a four game losing streak with their 3-1 triumph over NAC Breda in their domestic league and will be hoping that form continues against the Russians.
In other second-leg ties,Russia's Rubin Kazan meet Norway's Molde having scored two away goals, France's St.Etienne must overcome a 4-3 defeat to Danish side Esbjerg and Cyproit team Apollon hold a 2-0 advantage over Ligue 1's Nice.
|11||M. Frýdek jr.|
|Coach: J. Silhavy|
for J. Šural 84'
for M. Rabusic 86'
for S. Rybalka 90'
|European and EPL clubs circling for Jets|
|Millen ready to lead Palace recruitment|
|Wenger: Wilshere should ignore critics|
|CONCACAF Champions League Review: Herediano start strongly|
|Lambert excited by ´big asset´ Cole|
|Copa Sudamericana Review: Barcelona, Deportivo Capiata in the box seat|
|Brazilian Serie A Review: Luciano inspires Corinthians, Cruzeiro extend lead|
|Blanc: Di Maria transfer difficult|
|Klopp eager to deny Leverkusen|
|Blanc optimistic over Ibrahimovic fitness|
|Tiote will stay - Pardew|
|Bruce laments ´stupid´ McGregor mistake|
|UEFA Europa League Review: Tottenham in late turnaround, Astra shock Lyon|
|League Two Preview: Morecambe, Burton out to continue fast starts|
|Sassuolo 4 Cittadella 1: Second-half rally sees Sassuolo into Coppa fourth round|
|Howard to take US sabbatical|
|Lokeren 1 Hull City 0: McGregor error gifts Belgians victory|
|Rwanda given Wednesday hearing for disqualification appeal|
|Pochettino hails substitutes´ impact|
|Mackay apologises over text message scandal|
|Brandao suspended over Motta incident|
|Borussia Dortmund v Bayer Leverkusen: Klopp expecting tough start|
|QPR complete loan deal for Vargas|
|League One Preview: Fleetwood, Preston face home tests|
|Chelsea v Leicester City: Schurrle expecting Chelsea improvement|
|Southampton v West Brom: Koeman wary of Albion|
|AEL 1 Tottenham 2: Late turnaround gives visitors play-off edge|
|CAF Confederation Cup: Al Ahly, Nkana out to reach last four|
|Swansea City v Burnley: Monk expecting stern examination|
|Bender close to Leverkusen return|
|Morocco will host Club World Cup despite Ebola concerns - FIFA|
|Schneiderlin not allowed to leave, insists Koeman|
|Dyche confident Burnley can strengthen|
|West Brom eye Samaras signing|
|Aston Villa v Newcastle United: Lambert wants more Weimann goals|
|MLS Preview: Sounders look to bounce back at Portland, Johnson banned for DC|
|Klose eyes European football|
|Monk warns Swansea over complacency|
|De Jong set for Newcastle return|
|Crystal Palace v West Ham: No excuses from Millen|
|Pearson looking for Chelsea indication|
|Blanc wants Rabiot to stay|
|Bowyer reveals Hull approach for Rhodes|
|Atletico out to gatecrash Barca, Real party once again|
|Barcelona go back to the future|
|CSL Preview: Beijing Guoan, Dalian Aerbin hit the road|
|Westwood returns to Ireland squad|
|Millen confident on Palace job prospects|
|Pedro struck down by gastroenteritis|
|Championship Preview: Magath preaches patience, Ipswich host East Anglian derby|
|Ribery not ready for Bayern return - Guardiola|
|Ancelotti: Di Maria has asked to leave|
|Moody resigns from Palace post|
|Everton v Arsenal: Martinez denies Everton have advantage|
|Coventry agree Ricoh return|
|Allardyce eyes defensive improvements|
|FA to investigate Cardiff dossier|
|Simeone not expecting to retain title|
|Balotelli bids farewell to Milan team-mates|
|Wenger open to signings after Arteta blow|
|Martinez to wait on Kone, Oviedo before considering late signings|
|Ocampos believes in Jardim´s methods|
|Villas-Boas calls for Zenit focus|
|Jovetic predicts bright future at City|
|Hamren hoping for quick Ibrahimovic recovery|
|Van Gaal retains focus on team ethic|
|Martinez calls for Everton consistency|
|Oxlade-Chamberlain: Arsenal´s best will come|
|Benaglio retires from Swiss duty|
|MLS Review: Galaxy stun Rapids, Sounders held|
|CONCACAF Champions League Review: MLS clubs shine|
|Panama 4 Cuba 0: Hosts finally win|
|K. League Preview: In-form Jeonbuk out to increase advantage|
|Copa Sudamericana Review: Penarol poised to advance, General Diaz on track|
|Liga MX Preview: America target another win|
|J.League Preview: In-form Kashima, Tokyo face tests|
|Fresh faces in Australia squad|
|Copa Argentina Review: River Plate, Estudiantes des Caseros reach quarters|
|Girard rues wasteful Lille|
|Scholes: ´I am scared for United´|
|Patient Inter got just rewards - Mazzarri|
|UEFA Europa League Review: Inter win in Iceland|
|UEFA Champions League Play-offs Review: Away sides prosper in play-off first legs|
|Fulham 0 Wolves 1: Sako inflicts more misery on hosts|
|Bundesliga Preview: Klopp set to break record as Dortmund host Leverkusen|
|Bruce reveals Aboubakar interest|
|Kane ready to light up Premier League|
|Jerome joins Norwich|
|Bayern destined to dominate Bundesliga once again|
|Perfectionist Guardiola raises the bar|
|Pohang Steelers 0 Seoul 0: Last-eight tie on a knife edge|
|Rojo pens five-year deal at United|
|Bayern Munich v Wolfsburg: Badstuber wary of tough opening|
|Eredivisie Preview: Ajax and PSV lock horns in De Topper, Groningen face Den Haag|
|Ligue 1 Preview: Bordeaux and Saint-Etienne out to continue dream starts|
|Thai Premier League Review: 10-man Buriram survive Muang Thong test, BEC Tero defeated|
|QPR seal Fer capture|
|Modric aiming for further glory after extending deal|
|Dzeko pens new City deal|
|Marotta: Vidal was never for sale|
|Evian v Paris Saint-Germain: Champions wary of wounded hosts|
|Ulloa gains confidence from debut goal|
|Hamann hoping for competitive Bundesliga|
|Dortmund duo Kirch and Ji sidelined|
|Irvine will not rush Gamboa|
|Messi, Mascherano laud La Masia|
|Moses: Hughes reason for Stoke move|
|Lahm aware of Dortmund threat|
|Atletico Madrid v Real Madrid: Rodriguez targets winning goal after opening Real account|
|Wilshere urges focus for return leg|
|Milan: No Liverpool offer for Balotelli|
|Michu chat aided Fernandez switch|
|Western Sydney Wanderers 1 Guangzhou Evergrande 0: Tempers flare after Sydney triumph|
|Van der Vaart headlines Netherlands squad|
|CAF Champions League Preview: Dead rubbers brought to life by Zamalek appeal|
|UEFA open Tavecchio investigation|
|Napoli sign Villarreal´s De Guzman|
|My heart is at Bayern, insists Muller|
|Altidore at his happiest - Poyet|
|Barca to go to CAS after FIFA rejects appeal|
|Swansea confirm Fernandez signing|
|Leverkusen will not relax, says Schmidt|
|Modric pens new Real deal|
|Amat relishing Fernandez competition|
|Snodgrass out for six months|
|Di Maria is Real´s best - Simeone|
|Kompany hails City contract dealings|
|Higuain: Napoli have to qualify|
|Martinez backs Barkley to bounce back|
|Stjarnan ready to exploit Inter´s ´weaknesses´|
|No price-tag pressure for Liverpool´s Markovic|
|Courtois admits departure thoughts|
|Skrtel: Liverpool must defend ´as a group´|
|Duff predicts Chelsea success, ´worried´ for Fulham|
|CONCACAF Champions League Review: Portland shine in Guyana|
|Simeone: We have a ´50-50 chance´|
|Copa Sudamericana Review: Cerro Porteno win away, Huachipato start strongly|
|Ronaldo injury ´not serious´ - Ancelotti|
|Martino names Argentina squad|
|Supercopa ´still open´ - Alonso|
|Expect goals in Lille, Porto clash - Girard|
|Courtois wants Cech stay|
|Benitez backs Napoli to score|
|Real Madrid 1 Atletico Madrid 1: Ronaldo off at half-time as Real denied|
|League Two Review: Morecambe, Burton remain unbeaten, Portsmouth defeat Northampton|