Udinese must overcome a shock first-leg loss to Slovan Liberec if they wish to progress to the UEFA Europa League group stage on Thursday.
The Italians were stunned 3-1 at their home ground by the Czech Republic side, who are in excellent form having won 12 of their last 15 competitive matches.
Veteran striker Antonio Di Natale scored in both legs of Udinese's third-round qualifying match against Siroki Brijeg and the Serie A club will need the Italian international firing on all cylinders again if it is to overturn the deficit against Liberec.
Fellow Italian side Fiorentina will take a slender 2-1 advantage into their second leg at home against Switzerland's Grasshopper.
With two away goals in Zurich, Fiorentina will be favourites to progress but the plucky Swiss side could surprise.
English Premier League side Tottenham will take a five goal advantage into their second leg at White Hart Lane against Georgia's Dinamo Tbilisi, while Swansea City won 5-1 against Romania's Petrolul Ploiesti and should advance comfortably to the group stage.
Spanish side Sevilla will be confident of advancing to the group stage, holding a 4-1 lead over Poland's Slask Wroclaw.
The Poles nicked a shock lead in Sevilla before the home side pulled a goal back in the first half and then ran riot in the second stanza.
Sevilla's local rivals Real Betis welcome Czech Republic's Jablonec to the Estadio Benito.
Betis toiled hard for a 2-1 away win in the first leg and will be keen to bounce back against Jablonec after a 2-1 loss to Celta Vigo in La Liga on Sunday.
Stuttgart needs to overcome a 2-1 first-leg defeat in Croatia against Rijeka to advance to the group stage.
The Bundesliga club were hit by two late Rijeka goals to be 2-0 down before Vedad Ibisevic's 89th minute away goal salvaged a situation that was looking dire.
Other German representatives Eintracht Frankfurt are much more comfortable in their tie against Azerbaijan's Qarabag with two away goals in the bag before the second leg at home.
Stefan Aigner assisted both of Alex Meier's two goals in Azerbaijan in a 2-0 victory.
Dutch side AZ Alkmaar should have no issues advancing after a 3-1 first-leg win in Greece against Atromitos Athens.
The Greeks have not won any of their past six games and are expected to struggle in the second leg at the AFAS Stadion.
It is a different story for other Eredivisie team Feyenoord, who were beaten 1-0 by Kuban Krasnodar in the opening battle in Russia.
The Dutch giants snapped a four game losing streak with their 3-1 triumph over NAC Breda in their domestic league and will be hoping that form continues against the Russians.
In other second-leg ties,Russia's Rubin Kazan meet Norway's Molde having scored two away goals, France's St.Etienne must overcome a 4-3 defeat to Danish side Esbjerg and Cyproit team Apollon hold a 2-0 advantage over Ligue 1's Nice.
|11||M. Frýdek jr.|
|Coach: J. Silhavy|
for J. Šural 84'
for M. Rabusic 86'
for S. Rybalka 90'
|Lambert disappointed with refereeing decisions|
|Russian Premier League Wrap: Zenit back on top, Spartak close the gap|
|Leonardo: PSG tried to sign Ronaldo|
|Cocu defiant despite heavy PSV defeat|
|Premier League: Fulham 2 Aston Villa 0|
|Garcia delighted as Roma back on form|
|Paulinho hails Tottenham resilience|
|UEFA Champions League Preview: Manchester United v Shakhtar Donetsk|
|Hughes sees Stoke progression|
|Marcelo tips Kaka for FIFA World Cup recall|
|Pochettino sticks to attacking philosophy|
|Milner bemoans City travel sickness|
|Laudrup looking for striker boost|
|Juve will not miss Pirlo, says Mancini|
|Poyet has own goal concerns|
|Coloccini: We have learnt from our mistakes|
|Buffon fires Hart a World Cup warning|
|Hughton urges Hooper service|
|Hyypia hails ´important´ win over Dortmund|
|Clarke frustrated with penalty decision|
|Moyes confident in Manchester United squad|
|Mourinho: Chelsea are in trouble|
|Three arrested in new match-fixing probe|
|A-League: Melbourne Victory 1 Newcastle Jets 2|
|Allardyce furious with Nolan indiscipline|
|Keller: Korb deserved a red card|
|Balotelli still confident despite late miss|
|Benitez bemoans errors, Guidolin thrilled with draw|
|No worries for Madrid after Copa del Rey draw|
|Son expected goal and victory against Dortmund|
|Paraguay Division Profesional Wrap: Cerro Porteno finish Clausura unbeaten|
|MLS Cup: Sporting Kansas City 1 Real Salt Lake 1 (7-6 on pens)|
|Guardiola thrilled with Bayern´s complete performance|
|Garcia focused on attractive football, Roma´s fans - not Juve|
|Copa del Rey Wrap: Real held, holders Atletico all but through|
|Primeira Liga Wrap: Martinez sends Porto top, Estoril see off Pacos|
|Ligue 1 wrap: Five-star PSG back on track, Lorient march on|
|Eredivisie Wrap: Top three all win, RKC draw|
|Klopp confirms hospital visits for Bender, Sahin|
|Serie A Wrap: Napoli, Milan both held|
|Poyet disappointed by second-half performance|
|Bundesliga Wrap: Bayern, Leverkusen secure wins|
|Balotelli calls for better focus from Milan|
|Allegri blasts Milan after Livorno draw|
|Villas-Boas pleased with efficient Tottenham|
|Scottish Premiership Wrap: No winning start for Inverness boss, Dundee United go third|
|Blanc pleased with PSG response|
|Marseille sack Baup|
|Clarke rues missed chances in West Brom defeat|
|Premier League: Sunderland 1 Tottenham 2|
|Bundesliga: Borussia Dortmund 0 Bayer Leverkusen 1|
|Pulis predicts tricky December for Palace|
|Hughes praises Assiadi impact|
|Ribery glad to be back as Bayern run riot|
|Mackay rues Cardiff´s wastefulness|
|Pellegrini praises Southampton display|
|Chelsea lack killer instinct, Mourinho laments|
|Rodgers lauds prolific Suarez|
|Lallana: Southampton deserved to win|
|Ligue 1: Paris Saint-Germain 5 Sochaux 0|
|Football League Wrap: Notts County, Cheltenham Town clinch wins|
|Championship Wrap: Burnley go top, Derby win fifth in a row|
|Premier League: Liverpool 4 West Ham 1|
|Premier League: Crystal Palace 2 Cardiff City 0|
|Premier League: Stoke City 3 Chelsea 2|
|Premier League: Southampton 1 Manchester City 1|
|Bundesliga: Werder Bremen 0 Bayern Munich 7|
|Moyes confident on United prospects|
|Pardew: Old Trafford win among the best of my Newcastle career|
|FIFA announce World Cup fixture changes|
|Premier League: Manchester United 0 Newcastle United 1|
|Escriba plays down Elche hopes|
|Lambert wary of Meulensteen effect|
|A-League Wrap: Kewell´s Heart held, Mariners down Sydney|
|J.League Wrap: Sanfrecce defend title, Marinos beaten|
|Courbis set for Montpellier job|
|Rosler appointed Wigan manager|
|Poyet: Uruguay will beat England|
|Ferdinand unsure over Moyes´ late selection tactic|
|Win shows squad depth, says Conte|
|Blanc denies PSG defeat was inevitable|
|Barcelona ´obliged to win´, says Martino|
|Unbeaten Bayern streak doesn´t faze Guardiola|
|Gilardino Toronto-bound as Italian MLS legion grows|
|Manaus stadium built for the heat, says sports secretary|
|Valcke: USA, England in tough groups|
|Ranieri admires lowly Ajaccio|
|Copa del Rey Wrap: Barcelona arrest deficit to beat third-tier Cartagena|
|Wenger dismisses complacency fears|
|Primeira Liga: Benfica 2 Arouca 2|
|World Cup draw soundbites: The best of the reaction|
|Scottish Premiership: Motherwell 0 Celtic 5|
|Bundesliga: Nuremberg 1 Mainz 1|
|Ligue 1: Marseille 0 Nantes 1|
|Eredivisie: Utrecht 2 NEC 0|
|Serie A: Bologna 0 Juventus 2|
|Sabella satisfied with ´positive draw´|
|Boateng hails ´dream´ World Cup draw|
|Pekerman confident of Colombia progression|
|Wilmots: No world-class opponents in Belgium´s group|
|Santos gives Greece ´every chance´|
|Last 16 is France aim, says Deschamps|
|Kovac wary of tough FIFA World Cup draw|
|Premier League Preview: Arsenal v Everton|
|Hitzfeld expecting tense FIFA World Cup group|
|Spain not in ´Group of Death´, insists Del Bosque|
|Portugal will fight for progression, Bento says|
|Scolari happy with Brazil draw|
|Low: World Cup focus not just on United States|
|Van Gaal wary of tough group|
|Hoddle: Tough group can boost England|
|Prandelli happy with FIFA World Cup draw|
|Pele: We will make the final|
|Australia coach excited despite horror draw|
|Hodgson upbeat despite tough FIFA World Cup draw|
|Hangeland set for spell on the sidelines|
|Spain grouped with Netherlands at Brazil 2014 World Cup|
|Serie A Preview: Inter v Parma|
|World Cup Draw: Group G|
|World Cup Draw: Group H|
|World Cup Draw: Group F|
|World Cup Draw: Group E|
|World Cup Draw: Group D|
|World Cup Draw: Group C|
|World Cup Draw: Group B|
|Hughes confident of ending Chelsea hoodoo|
|Mourinho frustrated with fixture congestion|
|Moyes coy on Van Persie comeback|
|Enyeama extends Lille contract|
|Premier League Preview: Fulham v Aston Villa|
|Two sacked by Whitehawk following match-fixing charge|
|Lucio bemoans Inter errors|
|Pellegrini calm over Kompany fitness|
|Coloccini committed to Newcastle|
|Falcao to miss Ajaccio clash|
|Ronaldo set for Tuesday return|
|A-League Wrap: Perth back on track, Brisbane win in Adelaide|
|Allardcye warns of Suarez danger|
|Fully-fit Kagawa confident of improvement|
|Mandela´s ´hero´ Radebe hails leader|
|Rodgers: Sterling rejuvinated by rest|
|Reina: I´d help Mascherano make Napoli move|
|Pochettino confident despite injury blows|
|Martinez eyes Everton additions|
|Kompany desperate to stay fit|
|Alves: Comparisons to Guardiola´s Barcelona unfair|
|Bendtner vital for Arsenal - Arteta|
|Parreira: Mandela was ´a god´ to South Africans|
|Colombia Primera A Wrap: Atletico Nacional reach final|
|Alonso the key for Real, says Ancelotti|
|Karanka rejected Mourinho, Chelsea|
|Garde left disappointed by home draw|
|FIFA should reconsider seedings, says Prandelli|
|Mihajlovic given selection headaches|
|Tributes flow for Mandela|
|Matthaus: Germany ´definitely´ World Cup contenders|