Milan will look to bounce back from a disappointing defeat to Verona when they host PSV in the UEFA Champions League on Wednesday.
Massimiliano Allegri's side started their Serie A campaign with a 2-1 loss away to Andrea Mandorlini's side on Saturday, as two Luca Toni headers cancelled out Andrea Poli's opener.
But the Italian giants are in a favourable position to qualify for the Champions League group stages, after they secured a 1-1 draw in the first leg at the Philips Stadion last Tuesday.
Stephan El Shaarawy's first-half effort gave Milan the crucial away goal, but a Tim Matavz equaliser in the second half ensured the tie remains in the balance.
Allegri has several injury issues ahead of the game with striker Giampaolo Pazzini and centre-back Daniele Bonera both missing with knee problems, while midfielder Nigel de Jong remains a doubt.
The 46-year-old is fearful of a hangover from the loss to Verona, but warned that fitness issues in the squad could not be used as an excuse for failure.
"Losing like this is painful as it's the first week," he told reporters after the loss. "Especially as we have the important Champions League game against PSV on Wednesday.
"Some players have not managed to do much training but that cannot be an excuse."
Philip Cocu's PSV side are too looking to overcome a lacklustre league display, after they rescued a 1-1 away to Heracles on Saturday thanks to Park Ji Sung's 86th-minute equaliser, leaving them second in the Eredivisie table with 10 points from four games.
Defender Karim Rekik says the squad do not fear their illustrious opponents, but emphasised the importance of keeping a clean sheet in Italy.
"We are not afraid of Milan and we should not change our way of playing because we are playing at the San Siro," he told NUsport.
"I think it is especially important to keep the (score to) zero. If that works, then we definitely have a chance."
Cocu has no fresh injury worries ahead of the fixture, with Luciano Narsingh (knee) and Oscar Hiljemark (groin) likely to be the only absentees.
|2||M. De Sciglio|
|10||K. Boateng||9' 77'|
|34||N. de Jong|
|45||M. Balotelli||55' 62'|
|92||S. El Shaarawy|
|Coach: M. Allegri|
for S. El Shaarawy 74'
for S. Muntari 82'
for K. Boateng 86'
|Klose lauds Ronaldo after scooping record|
|Iran refute Susic claims|
|Fernandez named Deportivo boss|
|Argentina have no chance, says Robben|
|Hierro to replace Zidane as Real first-team coach|
|Rhodes signs new Rovers deal|
|Arsenal complete Sanchez swoop|
|Inzaghi backs under-fire Balotelli|
|Defeat has overshadowed display - Vlaar|
|Maradona: Germany full of themselves|
|Barry hoping for England recall|
|Green extends QPR stay|
|Shanghai Shenhua 1 Guangzhou Evergrande 2: Rong leaves it late in dramatic win|
|Germany hope for Brazilian support|
|Torino striker Cerci in demand|
|FIFA critcised following Mascherano incident|
|Bernat happy at Bayern despite bad memories|
|Giggs backs Van Gaal to thrive at Old Trafford|
|Tadic can fill Lallana void - Koeman|
|New five-year deal for Nasri|
|Barcelona release injury-hit Cuenca|
|Suarez appeal rejected|
|La Decima a reflection of Di Stefano - Perez|
|Buoyant Mazzarri eager for Inter success|
|Mandzukic joins Atletico|
|Van Gaal criticises third-place play-off|
|Halilhodzic yet to decide future|
|Mandzukic eager for Simeone link-up|
|Davies hoping for Hull deal|
|Poyet hopeful over Altidore fitness|
|Diego close to ´dream´ Fenerbahce move|
|Inter loan out youngsters|
|Fired-up Cole can inspire Villa, claims Lambert|
|Hughes hailed for winning over Brit doubters|
|Hajrovic signs for Bremen|
|Hull can buck Europa League trend, says Meyler|
|Mertesacker talks up German chances|
|Swansea reveal Tottenham contact over Davies, Sigurdsson|
|Lloris pens five-year deal at Tottenham|
|Fernandinho: ´The pain is big´|
|MLS Preview: Portland aim for swift revenge against Seattle|
|Sabella: Germany have an advantage|
|Second Argentine journalist dies in Brazil|
|Aguero: Argentina defied critics|
|Impressive Mascherano thrilled with final´s berth|
|Zuniga offered protection by Colombia|
|Germany vowed not to ´humiliate´ Brazil|
|Hong resigns from South Korea post|
|Third-choice Vlaar ´wasn´t nervous´|
|Van Gaal: I wanted Krul in the shootout|
|Argentina: Key factors in reaching the final|
|Sabella revels in semi-final win|
|Proud Robben feels pain of World Cup exit|
|FIFA World Cup: Netherlands 0 Argentina 0 (after extra time, 2-4 on penalties)|
|Susic signs two-year extension with Bosnia-Herzegovina|
|Hummels in race to make World Cup final|
|Scolari still baffled by Brazil collapse|
|Spendlhofer and Benedetti leave Inter|
|Neymar ´recovering well´ from injury|
|Villarreal sign Jonathan dos Santos|
|Arteta happy at Arsenal, insists agent|
|Birsa makes Chievo loan switch|
|FIFA suspends Nigeria over political interference|
|Di Stefano funeral held in Madrid|
|Hangeland scathing of ´difficult´ Magath|
|Thiago Silva in fan plea|
|Isgrove earns fresh one-year deal at Southampton|
|Morata edges closer to Juve switch|
|Nugent pens two-year extension at Leicester|
|Gomez delight with ´perfect´ Germany|
|Costa Rica to discuss Pinto future|
|Arfield agrees Burnley extension|
|Allardyce targets four more signings|
|K.League Review: Jeonnam close gap on Pohang, Jeonbuk|
|Maradona: Thrashing damages Brazil´s image|
|Kasami makes Olympiacos move|
|Chelsea complete Pasalic signing|
|Helenius makes temporary Aalborg return|
|Higuain set for Napoli stay|
|Basta targets return to Europe with Lazio|
|Lewandowski willing to adapt for Bayern|
|New Hull deal for Jakupovic|
|Atletico agree Mandzukic deal, claims Sammer|
|Fulham seal Stafylidis loan|
|Alves pens new Valencia deal|
|Ochoa to take time over future|
|Brown could miss three months|
|Adams: Norwich will not overspend|
|Gundogan unsure when rehab can step up|
|Stoke chairman wants long Begovic stay|
|Brazilian media reacts to semi-final exit|
|Icardi vows to remain at Inter|
|Robben is player of the World Cup, says Kluivert|
|Klose focused on final after breaking record|
|Prandelli takes aim at Balotelli, Rossi|
|Schweinsteiger sorry for Brazil battering|
|Brazil scarred for life, says Fred|
|Sabella: Argentina ´have already won´|
|Muller stunned by rout|
|Low lauds ice-cool Germany|
|Tearful Luiz apologizes for semi-final loss|
|Scolari sorry for ´catastrophic´ Brazil hammering|
|Brazil join sport´s biggest chokers|
|Reality kills Brazilian dream on a surreal night|
|FIFA World Cup: Brazil 1 Germany 7|