Tottenham and Swansea City both hit five goals to all but secure qualification to the group stages of the UEFA Europa League on Thursday.
Andros Townsend was particularly impressive for Tottenham, who ran riot in a 5-0 away victory to Georgian outfit Dinamo Tbilisi.
The winger scored one and provided assists for Paulinho and Roberto Soldado as Andre Villas-Boas' side eased into a 3-0 lead. Danny Rose added a stunning curling effort from long range before Soldado notched his second to complete the rout.
Tottenham's fellow Premier League club Swansea were equally dominant in their 5-1 demolition of Petrolul Ploiesti at the Liberty Stadium.
A Wayne Routledge double sandwiched Michu's effort as Swansea raced into a 3-0 lead at half-time.
Close-season signings Wilfried Bony and Alejandro Pozuelo added to the tally after the break, before the Romanian side pulled one back three minutes short of the full-time whistle through Gheorghe Grozav's superb overhead kick.
Salzburg were also 5-0 victors, as they dominated Zalgiris in their home leg at the Red Bull Arena.
Serie A outfit Udinese face an uphill battle to save their Europa League campaign though, as they suffered a shock 3-1 defeat at home to Slovan Liberec.
Gabriel Silva had cancelled out Sergiy Rybalka's opener, but the Czech outfit scored twice against the run of play in the second half through Dzon Delarge and Ondrej Kusnir to take control of the tie.
Elsewhere, Sevilla recovered from an early setback to defeat Slask Wroclaw 4-1 at the Estadio Ramon Sanchez Pizjuan.
Marco Paixao put the away side ahead, but Ivan Rakitic, a double from Marko Marin and a strike from Kevin Gameiro ensured a comfortable win for the La Liga outfit.
Fiorentina will be confident of progression, as Juan Cuadrado and Mario Gomez helped Vincenzo Montella's side to a 2-1 win over Grasshopper Zurich at the Stadion Letzigrund.
Real Betis were also 2-1 winners away to Jablonec, while Rijeka and Tromso won by the same scoreline at home to Stuttgart and Besiktas respectively.
Meanwhile, Frankfurt, Standard Liege and Rubin Kazan all take 2-0 leads back to their home grounds, as they overcame Qarabag, Minsk and Molde.
The matches involving Kuban' Krasnodar and Feyenoord, Partizan Belgrade and Thun, Chornomorets and Skenderbeu Korce and Rapid Vienna and Dila all ended 1-0 to the home teams, while Braga won by the same result away at Pandurii Targu Jiu.
Dnipro Dnipropetrovsk and AZ Alkmaar earned 3-1 triumphs away to Kalju and Atromitos respectively, and there was also away success for Dynamo Kiev, who earned a 3-2 victory over Aktobe.
Ligue 1 side Saint-Etienne took the lead three times away to Esbjerg, but it was not enough to stop them falling to a 4-3 defeat courtesy of late strikes from Hans Henrik Andreasen and Peter Ankersen.
Maccabi Haifa, Apollon and Estoril all produced 2-0 victories at home to Astra Giurgiu, Nice and Pasching respectively.
And there was also 2-0 wins for Trabzonspor and Genk in their away matches with Kukesi and FH.
The fixtures between St Gallen and Spartak Moscow, Elfsborg and Nordsjaelland, Vojvodina and Sheriff and Zulte-Waregem and APOEL all finished 1-1.
|15||W. Routledge||14' 25'|
|Coach: M. Laudrup|
for W. Routledge 61'
for J. Shelvey 69'
for A. Williams 71'
|Dortmund put 17 past Olympians, Bremen hand out thrashing|
|Dinamo Zagreb confirm arrests of coach and club president|
|I didn´t know who Wimbledon guest Klopp was - Brown|
|LeBron James backs Liverpool captain Henderson for FIFA 16 cover.|
|Ramos: I am not negotiating with anyone|
|Valencia complete Mina swoop|
|United States v Japan: US seek final redemption|
|Hanousek consigns Celtic to defeat|
|Roma confirm Dzeko interest|
|Arsenal forward Podolski completes Galatasaray switch|
|Warm Dortmund welcome delights Tuchel|
|Silva vows to fight for Madrid place|
|Mancini hints at Shaqiri and Santon departures|
|Bojan raring to go after return from injury|
|Babel backs Firmino to shine at Liverpool|
|Falcao must wait to impress, warns Chelsea favourite|
|Bartomeu: Deal in place for Turan|
|Parejo re-signs with Valencia|
|MLS Review: Sounders return to winning ways|
|Klinsmann unhappy with USA performance|
|High hopes for Paraguay - Diaz|
|Gareca: More to come from Peru|
|Gerrard had European offers|
|Argentina out to spoil Chile´s party - Martino|
|Sampaoli: Chile won´t change style|
|Di Maria will come good at United - Rojo|
|Peru 2 Paraguay 0: Gareca´s men finish third at Copa|
|United States 4 Guatemala 0: Klinsmann´s men win comfortably|
|´I’d prefer no-one to know my name´ - Bassett|
|Matthews completes Sunderland move|
|Podolski set for Galatasaray medical|
|Gundogan inspires Dortmund victory|
|Inter confirm Montoya capture|
|Murillo joins Inter, as Kuzmanovic and Obi depart|
|Falcao signing not a risk, says former Chelsea star|
|Deeney agrees new Watford deal|
|Confidence and service the key to Falcao success at Chelsea|
|No bids for ´Chelsea target´ Baba, claim Augsburg|
|Derby swoop for Ince|
|Fiorentina consider legal action over Salah ´no-show´|
|Chelsea the team to beat in the Premier League, says Neville|
|Storari exits Juve for Cagliari|
|UEFA removes FFP restrictions on Man City and PSG|
|West Brom hope for new owners within the month|
|Chelsea agree loan deal for Falcao|
|Kuyt eyes trophies on Feyenoord return|
|Chile v Argentina: History beckons ahead of Copa America final|
|Wallace extends Monaco loan|
|Mihajlovic wants to instill fear factor at Milan|
|Mignolet improving at Liverpool - Grobbelaar|
|Mumbai City name Anelka player-manager|
|Olivia the parrot predicts Japan to win Women´s World Cup|
|Lusitans coach blasts Bilic´s ´lack of respect´|
|Sakho eyes more Europa League wins|
|Gareca wants Peru to keep building|
|Chile ´no chance´ if Argentina produce their best - Diaz|
|Ocampos joins Marseille permanently|
|Europa League Review: Cloud-nine Brondby ignite opening round|
|West Ham 3 Lusitans 0: Sakho nets twice at start of Europa League journey|
|Holebas makes Watford move|
|Milan secure Adriano signing|
|Peru v Paraguay: Diaz counts cost of semi-final loss|
|Bastia hit out at reports of extra debt|
|Hernandez has successful surgery|
|Odemwingie signs one-year Stoke extension|
|Uth signs for Hoffenheim|
|Henen seals Everton return|
|Cattermole pens long-term Sunderland deal|
|United States v Guatemala: Klinsmann backs Dempsey ahead of Gold Cup warm-up|
|West Ham working on Jenkinson return - Gold|
|Milan agree deal for Bacca|
|Real buy back Vazquez from Espanyol|
|Richards leaves Swansea for Fulham|
|McShane signs for Reading|
|Giggs tells youngsters to seize US chance|
|Hammond pens Leicester extension|
|Only Schweinsteiger can decide Bayern future - Guardiola|
|Cech plans to play until he´s 40|
|Montoya arrives in Milan ahead of Inter move|
|Hernandez out of Gold Cup|
|US asks Switzerland to extradite seven FIFA officials|
|MLS Preview: Sounders seek momentum switch|
|Mexico 0 Honduras 0: Hernandez injury sours friendly|
|Hernandez taken to hospital|
|Garay in doubt for Copa America final|
|Wambach: USA peaking for World Cup final|
|Bassett ´an absolute hero´ despite own goal - Sampson|
|Japan 2 England 1: Late own goal breaks English hearts|
|Salvo quits as Valencia president|
|Costa not Ribery cover - Bayern director Sammer|