Tottenham and Swansea City both hit five goals to all but secure qualification to the group stages of the UEFA Europa League on Thursday.
Andros Townsend was particularly impressive for Tottenham, who ran riot in a 5-0 away victory to Georgian outfit Dinamo Tbilisi.
The winger scored one and provided assists for Paulinho and Roberto Soldado as Andre Villas-Boas' side eased into a 3-0 lead. Danny Rose added a stunning curling effort from long range before Soldado notched his second to complete the rout.
Tottenham's fellow Premier League club Swansea were equally dominant in their 5-1 demolition of Petrolul Ploiesti at the Liberty Stadium.
A Wayne Routledge double sandwiched Michu's effort as Swansea raced into a 3-0 lead at half-time.
Close-season signings Wilfried Bony and Alejandro Pozuelo added to the tally after the break, before the Romanian side pulled one back three minutes short of the full-time whistle through Gheorghe Grozav's superb overhead kick.
Salzburg were also 5-0 victors, as they dominated Zalgiris in their home leg at the Red Bull Arena.
Serie A outfit Udinese face an uphill battle to save their Europa League campaign though, as they suffered a shock 3-1 defeat at home to Slovan Liberec.
Gabriel Silva had cancelled out Sergiy Rybalka's opener, but the Czech outfit scored twice against the run of play in the second half through Dzon Delarge and Ondrej Kusnir to take control of the tie.
Elsewhere, Sevilla recovered from an early setback to defeat Slask Wroclaw 4-1 at the Estadio Ramon Sanchez Pizjuan.
Marco Paixao put the away side ahead, but Ivan Rakitic, a double from Marko Marin and a strike from Kevin Gameiro ensured a comfortable win for the La Liga outfit.
Fiorentina will be confident of progression, as Juan Cuadrado and Mario Gomez helped Vincenzo Montella's side to a 2-1 win over Grasshopper Zurich at the Stadion Letzigrund.
Real Betis were also 2-1 winners away to Jablonec, while Rijeka and Tromso won by the same scoreline at home to Stuttgart and Besiktas respectively.
Meanwhile, Frankfurt, Standard Liege and Rubin Kazan all take 2-0 leads back to their home grounds, as they overcame Qarabag, Minsk and Molde.
The matches involving Kuban' Krasnodar and Feyenoord, Partizan Belgrade and Thun, Chornomorets and Skenderbeu Korce and Rapid Vienna and Dila all ended 1-0 to the home teams, while Braga won by the same result away at Pandurii Targu Jiu.
Dnipro Dnipropetrovsk and AZ Alkmaar earned 3-1 triumphs away to Kalju and Atromitos respectively, and there was also away success for Dynamo Kiev, who earned a 3-2 victory over Aktobe.
Ligue 1 side Saint-Etienne took the lead three times away to Esbjerg, but it was not enough to stop them falling to a 4-3 defeat courtesy of late strikes from Hans Henrik Andreasen and Peter Ankersen.
Maccabi Haifa, Apollon and Estoril all produced 2-0 victories at home to Astra Giurgiu, Nice and Pasching respectively.
And there was also 2-0 wins for Trabzonspor and Genk in their away matches with Kukesi and FH.
The fixtures between St Gallen and Spartak Moscow, Elfsborg and Nordsjaelland, Vojvodina and Sheriff and Zulte-Waregem and APOEL all finished 1-1.
|15||W. Routledge||14' 25'|
|Coach: M. Laudrup|
for W. Routledge 61'
for J. Shelvey 69'
for A. Williams 71'
|Mkhitaryan keeping fingers crossed over injury|
|Casillas left frustrated by Alex Telles red card|
|Anything can happen at King Power Stadium – Away goal lifts Schmeichel|
|Ranieri hails Leicester´s ´big heart´ in Sevilla loss|
|Krasnodar celebrate eighth anniversary by eliminating Fenerbahce|
|Home bird Rooney not suited to China - Phil Neville|
|Ramos rejects claims of bad Real Madrid attitude|
|Porto 0 Juventus 2: Substitutes Pjaca and Alves give Bianconeri command|
|Sevilla 2 Leicester City 1: Vardy´s strike tees up second leg after Schmeichel heroics|
|Madrid lead is not worth anything – Zidane|
|Dropped Bonucci must adapt to the rules – Marotta|
|I cannot do what Man City did at Chelsea - Mourinho withering over FA Cup schedule|
|Marcelo: Real Madrid must learn from horror start at Valencia|
|Manchester United head to Wembley brimming with confidence – Smalling|
|Valencia 2 Real Madrid 1: Zaza stunner hands title hope to Barcelona|
|Manchester United duo Mkhitaryan and Carrick set to miss EFL Cup final|
|Alba: Luis Enrique the best coach for Barca|
|Sorry for that poor guy - Sane apologises after costing punter huge windfall|
|Saint-Etienne 0 Manchester United 1 (0-4 agg): Mkhitaryan on target before injury scare|
|Kessie dreaming of Manchester United move|
|Kane refuses to blame ´incredible´ Wembley for Champions League exit|
|Mkhitaryan limps out of Manchester United Europa League clash|
|De Sciglio back in AC Milan training|
|Perez ´really comfortable´ after settling at Arsenal|
|Lallana signs three-year extension at Liverpool|
|Lyon have already discussed replacing Lacazette - Aulas|
|Low pleased to avoid fatigue after Euro 2016 campaign|
|Some teams are beaten before kick-off - Hazard hails Chelsea home form|
|AFC Champions League Review: Misery for history-making Yuen-ting, Ramires boosts Jiangsu|
|Spalletti not interested in Europa League favourites tag|
|Ventura: Balotelli´s latest signs not positive|
|Vela not expecting Real Sociedad Champions League return|
|Schone renews for two years at Ajax|
|Pochettino calls for patience in Tottenham trophy hunt|
|Demirbay earns two-year Hoffenheim extension|
|Origi eyeing first team place at Liverpool|
|Tottenham legend King encourages Alli to keep his edge|
|Pochettino: Spurs must wait for Rose return|
|Romero eyes Europa League title ahead of birthday trip to Saint-Etienne|
|Mowbray tasked with saving struggling Blackburn|
|Four more years? Celtic´s Dembele not stressing amid Real Madrid links|
|RB Leipzig or Salzburg Champions League ban ´hypothetical´ - UEFA|
|Manchester United have world-class players in every position - Forster|
|James: Zidane´s rotation does not affect Real Madrid|
|Redan to snub Manchester United and sign Ajax deal|
|Giovinco turned down China move ´for now´ - agent|
|Guardiola wanted to destroy Monaco´s 4-4-2, says Fabinho|
|Sagna hails Stones after ´vital´ Manchester City goal|
|Deulofeu loves AC Milan but future ´depends on Barcelona´|
|Monaco lacked intelligence, says frustrated Falcao|
|That is why Manchester City wanted me - Guardiola relishes Champions League thriller|
|Tianjin deny Rooney bid but admit Aubameyang talks|
|Deportivo Saprissa 0 Pachuca 0: Champions League quarter-final evenly poised|
|Gameiro angered by substitution in Atletico win|
|´I give nothing for free´ – Mourinho tells Shaw to learn from Mkhitaryan|
|Champions League quarter-finals still possible for Monaco, says Silva|
|Guardiola asks me for more, more, more - Aguero happy to fight on at Manchester City|
|It was like ice hockey - Monaco vice-president stunned by Champions League clash|
|Proud Griezmann eyes more Atletico history|
|Toure marvels at Caballero heroics in Manchester City-Monaco thriller|
|Buffon hopes to play well against Casillas|
|Schmidt: It is easy to see how Atletico Madrid have reached two finals in three years|
|Falcao penalty miss was key – Jardim|
|Guardiola: If one team can score a thousand, million goals it is Monaco|
|Griezmann hails ´brilliant´ Gameiro as Atletico see off Leverkusen|
|Simeone all smiles after Atletico dismantle Leverkusen|
|Spot-kick revision pays off for Caballero|
|Championship Review: Huddersfield boost top-two hopes, Wednesday beaten|
|Toprak laments bad result as Leverkusen lose at home to Atletico|
|Aguero grapples for glory as strikers shine in Manchester City v Monaco|
|Bayer Leverkusen 2 Atletico Madrid 4: Simeone´s side in control|
|Manchester City 5 Monaco 3: Guardiola´s side prevail in all-time classic|
|AFC Champions League Review: Al Rayyan and Al Ahli off to winning starts|
|Ranieri: Sevilla game can be a turning point for Leicester|
|Allegri confirms Bonucci absence after row|
|Nuno confident Porto can beat Juventus|
|Matthaus encourages Gotze to stay at Dortmund|
|Martial: I love Manchester United and I want to stay|
|I would never force out Manchester United legend Rooney - Mourinho|
|Anderlecht insist Tielemans not leaving on the cheap|
|Leicester can´t afford to live in the past, warns Sampaoli|
|Porto´s home comforts, shot-shy Leicester & Sevilla meet - Champions League in Opta numbers|
|Puyol backs Barcelona for Champions League miracle|
|Sutton´s pie-munching keeper Shaw resigns|
|Coyle leaves struggling Blackburn|
|Sampaoli noncommittal on Sevilla future despite contract offer|
|Higuain backs Dybala to become ´among the best in the world´|
|Ancelotti escapes punishment for middle finger|
|Pie-eating Sutton goalkeeper´s antics under investigation|
|AFC Champions League Review: 2014 winners Wanderers thrashed, Hulk inspires 10 men|
|Zidane reveals Ronaldo´s favourite position|
|Lippi backs Allegri for Juve stay|
|Zidane: Isco knows I love him|
|Rooney returns to United training|
|Higuain confident Juventus can win Champions League|
|Giggs the dream pro-am partner for Manchester United fanatic McIlroy|
|Kane hopes Spurs can get used to Wembley|
|Hazard: I gave everything to come back|
|Like Cantona, Ibrahimovic embraces United pressure - Giggs|
|Wenger: Perez deserves more chances|
|Wenger denies using Sanchez was risky|
|Tite: I wish Messi was born in Brazil|
|Jardim praises ´great striker´ Falcao|
|Reported Barcelona target Sampaoli offered Sevilla extension|
|´Angry´ Messi didn´t celebrate because of criticism – Bauza|
|´He is going to have to do it himself´ – Guardiola backs Aguero|
|Toure backs Sterling and Sane for the top|
|Pique: Barcelona were in deep s*** when Luis Enrique arrived|
|Thoughts of Bayern mauling stopped Wenger from enjoying Arsenal FA Cup win|