Champions Juventus open the new Serie A season with a trip to one of only the three grounds they lost at in 2012-13.
Antonio Conte's side face Sampdoria at Stadio Luigi Ferraris - where they were beaten 3-2 on the final day of last season - on Saturday.
Juventus have made significant additions to their squad ahead of the new term, with Carlos Tevez and Fernando Llorente the stand-out names.
Both players will be hoping to open their accounts for their new club on the first day, while Manolo Gabbiadini is set to make his Sampdoria debut against his former side.
Napoli have also had a productive close-season as they attempt to close the gap on Juventus, having finished second in Serie A in 2012-13.
Rafael Benitez has replaced Walter Mazzarri in the hot-seat and he will have a host of new names available for Sunday's visit of Bologna.
Star striker Edinson Cavani may have left, but Benitez has added Pepe Reina, Gonzalo Higuain, Dries Mertens, Jose Maria Callejon and Raul Albiol to his squad.
However, they will have to be careful against a Bologna side that won twice at the Sao Paolo last season, scoring three goals on both occasions in the league and the Italian Cup.
Mazzarri left Naples to join Inter and he begins his tenure at San Siro at home to Genoa on Sunday.
Inter had a poor campaign under Andrea Stramaccioni last term, and the new coach is expected to make wholesale changes in order to make sure the club once again challenges at the top of the table.
Genoa have not beaten Inter since 1994, although they did pick up draws in both games last season.
Serie A new boys Verona, Livorno and Sassuolo all face tough trips on the opening weekend of the season.
Verona welcome Milan side off the back of Masimiliano Allegri's side's 1-1 draw with PSV in the UEFA Champions League play-off round on Tuesday.
New Roma coach Rudi Garcia takes charge of his first game in their visit to Livorno. The Frenchman has made 13 new signings in the close-season, including highly-rated Dutch midfielder Kevin Strootman.
Sassuolo's first Serie A game in their 91-year history sees them travel to face Torino.
Head coach Eusebio Di Francesco guided the club to the Serie B title by three points last year, and he will be hoping they can cause an upset against a Torino side who struggled in the top flight last season.
Elsewhere, Cagliari face Atalanta, Lazio and Udinese go head-to-head at Stadio Olimpico and Vincenzo Montella's Fiorentina - who have signed the likes of Joaquin and Mario Gomez in the close-season - host Catania.
|1||Angelo Da Costa|
|29||L. De Silvestri|
|Coach: D. Rossi|
for M. Eramo 72'
for D. Gastaldello 72'
for G. Berardi 83'
|Pekerman: I have no say on Falcao´s Manchester United future|
|Buffon has studied England new boy Kane|
|Conte urges patience from Italy fans|
|Johnson tasked with keeping Cheltenham up|
|Rooney not keen on Serie A switch|
|Kane to make first England start|
|Colombia 3 Kuwait 1: Spot-on Falcao nears Iguaran record|
|Goal-shy Barkley eyes striker´s role|
|UEFA opens disciplinary proceedings against Montenegro and Russia|
|Draxler and Choupo-Moting back in training|
|Ghana v Mali: Last chance to impress before Giresse return|
|Wilson: Gibraltar getting stronger|
|Mata confident of Spain future|
|Armenia coach Challandes resigns|
|Hiddink rubbishes talk of Dutch negativity|
|Portugal v Cape Verde: Santos set to rotate|
|Loren hails Moyes for Sociedad surge|
|Cruyff brands Netherlands ´a disgrace´|
|Kick It Out backs Barnes over race comments|
|Argentina v Ecuador: Messi remains doubtful for friendly|
|Coates backs Hughes ambition at Stoke|
|Atletico able to call on Saul again|
|Italy v England Preview: Kane set to start after dream debut|
|Zidane would accept Real job|
|Hernandez frustrated by lack of Real opportunities|
|Spartak donate money to 102-year-old fan after robbery|
|Clasie pulls out of Netherlands squad|
|Italy´s Bertolacci out of England friendly|
|Newcastle post record profit as Ashley debt stays the same|
|Al Sadd: We want Xavi to bring tiki-taka|
|Lacazette expected frosty Saint-Etienne reception|
|Barnes: I can´t get back into management because I´m black|
|Rooney praises England aggression|
|Southgate tips Kane for return to U21s|
|Mexico v Paraguay: Goals in order for Copa America aspirants|
|Netherlands - Spain Preview: Wijnaldum rallies behind under-fire Hiddink|
|Peru v Venezuela: Sanvicente wants Venezuelan response|
|Carvalho confident of playing Juventus|
|Neymar demands protection after Medel stamp|
|MLS Review: RSL, Fire secure breakthrough wins|
|Firmino firmly on radar - Dunga|
|O´Neill delighted with second-half display|
|First-half dominance pleases Deschamps|
|Muller criticises Germany profligacy|
|Euro 2016 Qualifying Review: Portugal go top, Gibraltar make history in defeat|
|Liverpool the only English club I could play for - Suarez|
|France 2 Denmark 0: Lacazette off the mark in routine victory|
|Republic of Ireland 1 Poland 1: Long rescues vital point|
|Portugal 2 Serbia 1: Coentrao puts hosts top of Group I|
|Strachan hails ´terrific´ Gibraltar|
|Lafferty back playing with a smile on his face - O´Neill|
|Toure to reveal Ivory Coast future over coming days|
|Georgia 0 Germany 2: Reus and Muller on target for world champions|
|Northern Ireland 2 Finland 1: Lafferty inspires fourth qualifying success|
|Scotland 6 Gibraltar 1: Casciaro´s historic moment outshone by Fletcher´s hat-trick|
|France 2-0 Denmark: Lacazette and Giroud on target|
|Firmino hopeful of Copa America spot|
|Hummels considering options at Dortmund|
|Suarez goalless on Anfield return, but Balotelli nets stunner|
|Casciaro scores first competitive goal for Gibraltar|
|Fleetwood Town 1 Preston North End 1: Ball stunner claims share of derby spoils|
|Italy v England: Judge me on results, says Conte|
|Colombia v Kuwait: Falcao seeking another strong showing|
|Brazil 1 Chile 0: Firmino settles scrappy affair|
|Luxembourg v Turkey: Let´s kick on, urges Terim|
|South Africa 1 Nigeria 1: Zungu strikes late to earn draw|
|Smalling wants long-term United stay|
|South Africa 1-1 Nigeria: Last-gasp Zungu goal cancels out Musa strike|
|Italy call up Santon and Abate for England friendly|
|Switzerland v United States: Klinsmann eyes learning curve|
|Netherlands v Spain: Hiddink has players´ support, says Wijnaldum|
|A-League Review: Sydney end Wellington run, Adelaide suffer injury blows in Jets win|
|Henderson eyes long-term Liverpool future|
|I have nothing to prove - Bale|
|Brazil 1-0 Chile: Firmino gives Selecao battling victory|
|South Korea v New Zealand: All Whites looking to future|
|Japan v Uzbekistan: Hosts eye another win under Halilhodzic|
|MLS Review: Kaka nets in Orlando draw|
|Mexico 1 Ecuador 0: Hernandez, Corona help Herrera´s men to victory|
|Deschamps calls for France response|
|Dunga unfazed by pressure|
|Montenegro fan turns himself in after flare incident|
|Injured Messi not ready - Martino|
|Hodgson: Rooney not close to Charlton|
|Terim proud of Turkey|
|Hiddink happy with point|
|Euro 2016 Qualifying Review: Netherlands and Italy stage late escapes|
|Debutant Eder delighted with Azzurri bow|
|Argentina 2 El Salvador 0: Mancuello nets debut goal in straightforward win|
|Kovac not satisfied despite Croatia victory|
|Netherlands 1 Turkey 1: Huntelaar spares Hiddink from historic home loss|
|Ghana 1 Senegal 2: Konate brace downs Black Stars|
|Bulgaria 2 Italy 2: Controversial debutant Eder rescues Conte´s men|
|Morocco 0 Uruguay 1: Cavani spot-kick seals win|
|Al Sadd say talks with Xavi ongoing|
|McClean slams Sunderland´s handling of poppy controversy|
|Ghana 1-2 Senegal: Black Stars continue Afcon hangover|
|Cheltenham player diagnosed with cancer|
|Palace takeover talk premature - Parish|
|Odegaard becomes Euro qualifiers´ youngest starter|
|Job not done yet, Bale warns Wales|
|Israel 0 Wales 3: Brilliant Bale bags brace as Wales go top|
|Dunga backs Neymar to overhaul Pele´s Brazil goal record|
|League Two Review: Hartlepool climb out of drop zone, Cheltenham go bottom|
|El Salvador 0-2 Argentina: Martino's men triumph without Messi|
|League One Review: Canavan leaves it late to deny County|
|Freddy Adu signs with 11th team in as many years|
|Besiktas deny Cech, Danny rumours|
|Puerto Rico v Canada: Haber targets more momentum|
|Miranda not contemplating Atletico exit|
|Austin relaxed over England prospects|
|Manchester United should sign Ibrahimovic - Schmeichel|
|Ibe eyes Liverpool run-in|
|Bertrand called up by England as withdrawal of four players confirmed|
|A-League Review: Risdon nets stunner, Germano tames Roar|
|Panama v Costa Rica: Unbeaten run a secondary concern for Wanchope|
|Italy coach Conte shaken after death threats - FIGC chief|
|Barca fears over Alba eased|
|Schweinsteiger to start Germany qualifier|
|Akinfeev thanks fans after flare incident|
|Injuries offer Kane chance of first England start|
|Russian Football Union to protest following Montenegro abandonment|
|October comeback the target for injured Foster|
|Van der Vaart looks set to leave Hamburg|
|Bale focused on Wales - Coleman|
|Kluivert helps Curacao to victory|
|Hamstrung Alba returns to Barcelona|
|Macedonia v Australia: Confident visitors eye victory|
|Akinfeev to return to Moscow with Russia squad|
|Brnovic: Montenegro have no chance of qualifying|
|Russia had to resume after Akinfeev incident - Capello|
|Terim: Robben absence important|
|Brazil - Chile Preview: Winning is 'our only option' - Dunga|
|France - Denmark Preview: Olsen hits out at 'disrespectful' hosts|
|Morata keen to keep working|
|Canada 1 Guatemala 0: Haber heads Floro´s men to win|
|Difficult to find a place for Kane in starting XI - Hodgson|
|Difficult to find a place for Kane in starting XI - Hodgson|