Champions Juventus open the new Serie A season with a trip to one of only the three grounds they lost at in 2012-13.
Antonio Conte's side face Sampdoria at Stadio Luigi Ferraris - where they were beaten 3-2 on the final day of last season - on Saturday.
Juventus have made significant additions to their squad ahead of the new term, with Carlos Tevez and Fernando Llorente the stand-out names.
Both players will be hoping to open their accounts for their new club on the first day, while Manolo Gabbiadini is set to make his Sampdoria debut against his former side.
Napoli have also had a productive close-season as they attempt to close the gap on Juventus, having finished second in Serie A in 2012-13.
Rafael Benitez has replaced Walter Mazzarri in the hot-seat and he will have a host of new names available for Sunday's visit of Bologna.
Star striker Edinson Cavani may have left, but Benitez has added Pepe Reina, Gonzalo Higuain, Dries Mertens, Jose Maria Callejon and Raul Albiol to his squad.
However, they will have to be careful against a Bologna side that won twice at the Sao Paolo last season, scoring three goals on both occasions in the league and the Italian Cup.
Mazzarri left Naples to join Inter and he begins his tenure at San Siro at home to Genoa on Sunday.
Inter had a poor campaign under Andrea Stramaccioni last term, and the new coach is expected to make wholesale changes in order to make sure the club once again challenges at the top of the table.
Genoa have not beaten Inter since 1994, although they did pick up draws in both games last season.
Serie A new boys Verona, Livorno and Sassuolo all face tough trips on the opening weekend of the season.
Verona welcome Milan side off the back of Masimiliano Allegri's side's 1-1 draw with PSV in the UEFA Champions League play-off round on Tuesday.
New Roma coach Rudi Garcia takes charge of his first game in their visit to Livorno. The Frenchman has made 13 new signings in the close-season, including highly-rated Dutch midfielder Kevin Strootman.
Sassuolo's first Serie A game in their 91-year history sees them travel to face Torino.
Head coach Eusebio Di Francesco guided the club to the Serie B title by three points last year, and he will be hoping they can cause an upset against a Torino side who struggled in the top flight last season.
Elsewhere, Cagliari face Atalanta, Lazio and Udinese go head-to-head at Stadio Olimpico and Vincenzo Montella's Fiorentina - who have signed the likes of Joaquin and Mario Gomez in the close-season - host Catania.
|1||Angelo Da Costa|
|29||L. De Silvestri|
|Coach: D. Rossi|
for M. Eramo 72'
for D. Gastaldello 72'
for G. Berardi 83'
|Copa del Rey Wrap: Valencia scrape through, Bilbao thrash Celta|
|Primeira Liga: Maritimo 2 Braga 2|
|Galliani to stay at Milan|
|Klopp plays down Club World Cup|
|Schalke coach Keller not fearing the sack|
|Wilshere loses appeal against two-match ban|
|Zaha on Pardew´s radar|
|Milan will be my final club, says Abbiati|
|Anigo to remain at Marseille helm for time being|
|Premier League Preview: West Brom v Hull City|
|No Bankia involvement in Bale deal, says Perez|
|Galliani wants stronger Milan youth system|
|Rafinha extends Bayern contract|
|Premier League Preview: Stoke City v Aston Villa|
|Poyet: No excuse not to perform|
|Vanishing spray to be used at World Cup|
|Gabbidon praises Palace strike pair|
|Premier League Preview: Manchester United v West Ham|
|Hughton calls for Norwich City to show character|
|Premier League Preview: Fulham v Manchester City|
|Samaras attracting Lazio interest|
|Premier League Preview: Liverpool v Cardiff City|
|Rodgers backs Mackay at Cardiff|
|Foster back fit and raring for West Brom recall|
|De Boer agent denies Tottenham contact|
|Premier League Preview: Crystal Palace v Newcastle United|
|Hungary appoint Pinter as new coach|
|Iniesta signs new Barca contract|
|Rodgers coy over Suarez talks|
|Jagielka hopes for fresh faces at Everton to help top-four push|
|A-League: Central Coast 1 Wellington 0|
|Spain end top of FIFA rankings for sixth year running|
|Allardyce disappointed to draw Manchester City|
|Pascoe hails ´unbelievable´ Suarez|
|Vorm knee surgery brought forward|
|Blanc hails Cavani brace|
|Michu wants Aspas to join Swansea City|
|Hoeness plays down Bayern treble suggestions|
|Dzeko confident he can fill Aguero void|
|Moyes: No loan offers for Zaha|
|Kiessling calls for Leverkusen response|
|Matuidi: Cavani on par with Ibrahimovic|
|Yeboah set to join Borussia Monchengladbach|
|Rooney a ´chance´ to face West Ham|
|FIFA Club World Cup Preview: Bayern Munich v Raja Casablanca|
|Benzarti praises ´extremely talented´ Raja Casablanca|
|Ranieri unsure over Falcao return|
|Coupe de La Ligue Wrap: Cavani leads PSG to dramatic win|
|Copa del Rey Wrap: Real Madrid through as Sevilla crash out|
|Tottenham job appeals to Sherwood|
|Sherwood gutted after defeat|
|Hughes: United worthy winners|
|Moyes pleased to see United weather storm|
|Allardyce hails West Ham fight|
|Coppa Italia: Juventus 3 Avellino 0|
|Manchester clubs kept apart in League Cup semi draw|
|League Cup: Tottenham 1 West Ham 2|
|League Cup: Stoke City 0 Manchester United 2|
|FIFA Club World Cup: Raja Casablanca 3 Atletico Mineiro 1|
|Sheffield Wednesday, Wigan abandoned due to heavy rain|
|United face anxious Rooney wait over injury|
|Messi making good progress|
|Ramos ban overturned|
|Osvaldo charged by FA|
|In-demand Ince offered new Blackpool deal|
|Molde confirm Solskjaer approaches|
|Kramer keen to continue home record|
|Rodgers: Henderson has potential to get even better|
|Ruiz on Anderlecht´s radar|
|Swansea, Hull fined by FA over player behaviour|
|Leeds keen on re-signing Gradel|
|Leverkusen announce Ryu deal|
|Ribery named Bundesliga Player of the Year|
|Moyes: No Zaha interest|
|Barcelona, Real Madrid in European Commission investigation|
|Basel: No Tottenham approach for Yakin|
|Chelsea set for Guarin bid, agent claims|
|Lewandowski has Dortmund goal concerns|
|Pogba, Pirlo will not sign before Christmas, says Marotta|
|Guardiola convinced to join Bayern after ´meat´ and greet|
|Martinez: Everton seen as a ´perfect´ loan destination|
|Anderlecht ´perfect´ for Defour, says Van Holsbeeck|
|Watford appoint Sannino|
|Sakho feels ´lucky´ to play with Suarez|
|Lippi: Too many teams competing in Club World Cup|
|Moyes ´told Welbeck to learn from Rooney´|
|I would kill myself over match-fixing, says Gattuso|
|Hughes dismisses calls for Januzaj protection|
|Aguero ´could miss up to two months´|
|Guardiola lauds Ballon d´Or nominee Ribery|
|Liverpool open Suarez contract talks|
|Copa del Rey Wrap: Barcelona, Levante cruise through|
|A-League Preview: Derby date beckons for winless Heart|
|Pearson upbeat despite Leicester defeat|
|Poyet urges Sunderland to build on Chelsea win|
|Mourinho rues missed chances|