Tom Huddlestone and Jake Livermore could be handed their first starts for Hull City as they host Norwich City at the KC Stadium on Saturday.
Steve Bruce will manage his charges on home soil in the top-flight for the first time since they won promotion from the Championship in May.
The former Sunderland boss saw his side lose 2-0 to Jose Mourinho's Chelsea on Sunday, but he will take heart from a spirited performance in the second half.
Huddlestone and Livermore both joined from Tottenham on August 14, and made their bows off the substitutes' bench at Stamford Bridge.
And Bruce admitted he is considering making changes to his starting line-up for the fixture with Chris Hughton's team.
"We'll have a look," he told the club's official website. "I don't think it's any secret that the two lads from Tottenham came on and made a difference to us, so they both come into the reckoning.
"But I haven't finalised my XI yet. We've got a couple of days to go and a lot can happen in that time, so I'm not going to reveal my hand just yet."
Hull remain without Stephen Quinn who picked up a hamstring injury in a pre-season friendly with Eintracht Braunschweig, while defender Abdoulaye Faye is sidelined with a calf problem.
Norwich started their campaign with a 2-2 draw at Carrow Road against Everton, with Ricky van Wolfswinkel grabbing a debut goal to secure a share of the spoils.
Manager Hughton could opt to partner Van Wolfswinkel with new signing Johan Elmander, who received international clearance to feature on Friday.
Norwich were dealt a blow ahead of the game with the news winger Elliott Bennett is ruled out with a knee injury. The 24-year-old completed 90 minutes against Everton on Saturday, but now faces an extended spell on the sidelines.
"We have some bad news on Elliott Bennett," Hughton said in a pre-match press conference.
"He has a problem with his knee that will keep him out for a few months."
Bennett added on Twitter: "Will use this time to improve, I will come back stronger, faster and better as a player and a person."
Anthony Pilkington (knee) and Gary Hooper (shin) will also miss out, but Sebastien Bassong and Robert Snodgrass are back in contention after missing last weekend’s draw with Everton.
History suggests the fixture will be a close affair, with 11 league victories apiece in the head-to-head to record.
Norwich's last success in Hull came in April 2007, in a 2-1 victory.
|27||Ahmed El Mohamady|
|Coach: S. Bruce|
for S. Aluko 72'
for R. Brady 80'
for R. Koren 83'
|El Shaarawy open to Premier League move - agent|
|Reports: FIFA officials set to be arrested|
|Tigres UANL 2 Emelec 0 (2-1 agg): Mexicans through to Libertadores semis|
|Valencia ruled out of Copa America|
|Coleman: Bale being ignored by Real team-mates|
|Ruddy eyes England recall|
|Benteke will strike fear into Arsenal - Westwood|
|Howe named LMA Manager of the Year|
|Casillas reiterates desire to stay in Madrid|
|Dnipro players pay for fans´ tickets, transport|
|Galliani: I want Ancelotti back at Milan|
|Premier League: Manchester City season review - Frustrations as latest title defence falters|
|Injured Benfica star Salvio not for sale|
|AFC Champions League Review: Al Sadd suffer last-16 exit|
|Emery targeting historic victory|
|Toure and Wisdom pen new Liverpool deals|
|Stadium facilities drive Van Gaal potty|
|Blatter brushes off Figo´s ´dictatorship´ claims|
|Mavuba to end career at Lille after extending contract|
|Ipswich´s Bishop charged over betting breaches|
|Markevych admits to Dnipro nerves|
|Relegated Almeria to be deducted three points|
|Reims retain Guegan on one-year deal|
|Di Matteo departure could hinder Schalke swoop for Khedira|
|Bale planning Real Madrid stay|
|Del Bosque not prepared to risk Costa|
|West Ham earn Europa League berth|
|Pellegrini sure City will win title back|
|Low calls Herrmann into Germany squad|
|Gerrard will win trophies with Galaxy - Carragher|
|Frankfurt agree to let Schaaf leave|
|Hernandez hit with violent conduct charge|
|Bale set for 50th Wales cap against Belgium|
|Baines hoping for pre-season return|
|Bournemouth sign Boruc|
|Sevilla duo Rico and Vidal handed Spain calls|
|Premier League: Chelsea season review - Mourinho´s men canter to title|
|Speroni hints at possible Palace exit|
|Kane states Tottenham commitment|
|Boruc, Hooiveld leave Southampton|
|Oxlade-Chamberlain desperate to make FA Cup final|
|Roar turn to Aloisi|
|Di Matteo resigns as Schalke coach|
|Hughes hints at Moses return|
|Wenger hits out at scheduling|
|Terry backs Chelsea to dominate|
|Jets part ways with coach Stubbins|
|Kewell would love to manage Liverpool|
|Janmaat: Newcastle players failed Carver|
|Adelaide step up interest in Toni|
|Chelsea´s Drogba interested in MLS move|
|Otamendi wants to leave Valencia - agent|
|Benitez almost certain for Real job|
|Schneiderlin will leave for Champions League club|
|Kane planning to come back bigger and better|
|Moyes staying at Sociedad|
|Neil revels in Norwich promotion|
|Drogba interested in MLS move|
|Russian Premier League Review: Torpedo keep survival hopes alive|
|Turkish Super Lig Review: Galatasaray crowned champions as Fener have four sent off|
|Ghana 1 Madagascar 2: Simouri nets late winner|
|Galatasaray reclaim title as Fener implode|
|Ancelotti bears no grudge after Real sacking|
|Porto complete Bueno capture|
|Lazio 1 Roma 2: Yanga-Mbiwa settles Rome derby|
|Real sack Ancelotti|
|Route to the UEFA Europa League final: Sevilla|
|Derby sack McClaren|
|Eredivisie play-offs Review: Eagles relegated, NAC Breda earn reprieve|
|Inzaghi eager for Van Ginkel stay|
|Route to the UEFA Europa League final: Dnipro|
|Dani Alves plays down Champions League favourites tag|
|Middlesbrough 0 Norwich City 2: Jerome and Redmond send Neil´s men up|
|Renard takes over at Lille|
|Cancelo completes permanent Valencia move|
|Dnipro v Sevilla: Emery embracing chance at history|
|Kuchuk leaves Kuban Krasnodar|
|Desailly hails Terry and urges calm over Zouma|
|Guardiola has built on Heynckes´ Bayern legacy - Muller|
|Falcao thanks United fans|
|Zorniger takes Stuttgart role|
|Dani Alves to clarify Barca future after Champions League final|
|Pazzini in the dark over Milan future|
|Barzagli a doubt for Champions League final|
|Clough sacked by Sheffield United|
|Pardew eyeing ´quality´ signings|
|Carver encouraged by Ashley´s Newcastle promises|
|Gutierrez revels in Newcastle ´fairytale´|
|Relegation will haunt Hull - Chester|
|El Shaarawy eyes Italy call-up|
|Crouch delighted by headed goals record|
|Ancelotti all but confirms Real exit|
|Platini: FIFA will lack credibility if Blatter remains president|
|Bilbao duo pen new deals|
|Rooney: United can win title next season|
|Argentine football rocked by second death|
|Leicester must aim higher next season - Pearson|
|Monk negotiating new Swansea contract|
|Ox can play in cup final, says Wenger|
|Century of MLS goals ´surreal´ for Wondolowski|
|Copa Libertadores Preview: River not giving up hope|
|Cahill returns for Australia´s World Cup qualifier in Kyrgyzstan|
|MLS Review: Wondolowski joins 100-goal club|
|Toni on track for Hellas Verona´s maiden golden boot|
|Amid Ancelotti speculation, Galliani confirms Madrid trip|
|Berlusconi targets Ancelotti, Inzaghi remains committed to Milan|