Juan Carlos Ortega will begin his reign as Chivas Guadalajara coach with a trip to Queretaro in round seven of the Liga MX season.
The 45-year-old was appointed on Monday to replace Benjamin Galindo, who was sacked following the 4-2 defeat against Puebla.
That result saw Chivas slip to 15th in the Mexican Apertura championship, as an own goal from Kristian Alvarez and then a Matias Alustiza strike helped Puebla to their first win of the campaign.
Ortega - who worked as a coach at the club between 2003 and 2009 - will be hoping to reverse Chivas' slide when he takes charge for the first time against a Queretaro side who have won just once in their opening six games.
Elsewhere, Morelia will look to defend top spot when they take on America.
Carlos Bustos' side climbed to the summit with a 2-0 win over Atlas last time out, extending their unbeaten run to four games.
America, meanwhile, head into the match in decent form themselves after three straight wins, the most recent 1-0 against Pachuca.
Unbeaten Santos Laguna will once again look to in-form striker Oribe Peralta when they face a tough trip to Tijuana.
The Mexico international followed up two goals for his country against the Ivory Coast with a brace in last weekend's 3-0 victory against Tigres UANL as Santos Laguna climbed to third.
In other round-seven games, Toluca face second-placed Veracruz at the Estadio Nemesio Diez while Monterrey take on a Leon side coming off the back of four straight draws.
Strugglers Atlas and Pumas UNAM will both go in search of their first win of the season when they go head-to-head and rock-bottom Atlante must also snap a three-game losing streak if they are to overcome Pachuca.
Fifth-place Cruz Azul will bid for first away success of the season when they make the trip to Puebla, while Tigres UANL face a Chiapas side who have not beaten their hosts in league action in over four years.
|Lampard welcomes ´perfect´ NYCFC challenge|
|Shamrock Rovers 3 Progres Niederkorn 0: Waters at the double|
|Gerrard keen to emulate ´hero´ Beckham at Galaxy|
|UEFA Champions League Review: Red Imps make history, TNS breeze through|
|Ameobi extends Newcastle deal and heads for Cardiff|
|U.S. women celebrate World Cup victory with LA rally|
|Atletico agree Vietto deal|
|Silva appointed Olympiacos head coach|
|Presidential candidates unsure of Turan´s Barca switch|
|Toure keen to bounce back from ´disappointing´ campaign|
|El Salvador v Canada: Floro targets Gold Cup learning curve|
|Juve complete Zaza swoop|
|Costa Rica v Jamaica: Borges confident Wanchope´s men are ready|
|Marseille snare Sarr|
|Italy coach Conte to stand trial in match-fixing case|
|Castan keen to repay Roma´s faith|
|Rami thrilled to reunite with ´best coach´ Emery at Sevilla|
|Lusitans v West Ham: Tomkins seeks to silence minnows|
|Kagawa shines as Dortmund hit six in Japan|
|Alonso tips Gerrard for Galaxy glory|
|Firmino seeks self-improvement with Liverpool|
|Buffon bids farewell to Pirlo|
|Sterling named Europe´s ´most valuable´ young player|
|Casillas´ agent reveals Porto offer|
|Southampton bring in Martina|
|Dundee United accept Celtic´s Ciftci bid|
|McArthur pens new Palace deal|
|Bartomeu rules out Barca move for Pogba this year|
|Spurs have to be better now - Bentaleb|
|Milner expects central role|
|Micronesia thrashed again, this time 46-0|
|Marchisio: I cannot be Pirlo´s heir|
|Inter aiming for Champions League return - Icardi|
|UEFA Europa League Preview: Brondby and Slovan to protect handsome leads|
|Bentaleb pens new long-term deal at Tottenham|
|Barca agree Turan deal|
|FIFA bans Mayne-Nicholls|
|United States v Honduras: Klinsmann demands improvement ahead of Gold Cup opener|
|CONCACAF institutes extensive reforms in wake of FIFA corruption scandal|
|Mauri completes Milan move|
|City sign Turkey striker|
|Women´s World Cup final draws huge US TV ratings|
|My first Chelsea team better than current crop - Drogba|
|Bertrand set for lay-off after knee surgery|
|New five-year Juve deal for Marchisio|
|Allegri extends Juve contract|
|Koeman reiterates Alderweireld interest|
|Valencia bag Bakkali|
|New York City FC complete Pirlo capture|
|Panama v Haiti: Collat ready to challenge the best of CONCACAF|
|UEFA Champions League Preview: Harrison eyes TNS progression|
|FIFA sanctions Yemen for fielding ineligible player|
|Toulouse rubbish Ben Yedder exit reports|
|Mourinho ´knows what he´s doing´ with Falcao signing|
|Watford shell out club-record fee for Capoue|
|Braafheid signs Lazio extension|
|Nani finalises Fenerbahce move|
|Liverpool confirm O´Driscoll appointment|
|Liverpool have to start better - Lucas|
|USA simply too good - Sasaki|
|Portland Timbers 1 San Jose Earthquakes 0: Jewsbury wins it in stoppage time|
|No move yet for Van Persie|
|Lloyd wins Golden Ball, Silver Boot awards|
|Mascherano: I never grabbed Banega|
|Dunga requested Brazil not appeal Neymar´s suspension|
|United States 5 Japan 2: Lloyd stars with hat-trick|
|Fiorentina deny Inter criticism|
|Nani relishing Fenerbahce opportunity|