Four former winners enter the UEFA Europa League for the play-offs hoping to secure one of 30 group stage places.
Sevilla - who won the tournament in 2006 and 2007 – welcome Slask Wroclaw to Ramon Sanchez Pizjuan hoping to build on their strong start to the season with a home victory.
The Spanish side have seen important players leave during the close-season – Jesus Navas, Gary Medel and Alvaro Negredo all moved to the Premier League in England – but with the arrival of Kevin Gameiro and continued development of Geoffrey Kondogbia means hopes remain high.
Wroclaw finished third in the Ekstraklasa last season but have started the new campaign terribly with no win in their opening four matches.
The Polish side are trying to get beyond the play-off stages of the Europa League in its current format for the first time having fallen to Helsingborg and Hannover in the past two seasons.
Andre Villas-Boas' Tottenham side - quarter-finalists last season - will be aiming to go further in the competition this time but face a trip to Georgia against Dinamo Tbilisi.
The Premier League side will have new signings Roberto Soldado and Etienne Capoue available for their trip, although Gareth Bale is unlikely to feature as speculation continues about his future at White Hart Lane.
Another former winner of the competition - in its previous guise as the UEFA Cup - are Eintracht Frankfurt, and Armin Veh's side face a trip to Azerbaijan in the first leg of their tie with Qarabag.
After a tough start to the Bundesliga season – they have lost both their games, including a 6-1 defeat to Hertha Berlin on the opening weekend – Veh has added Czech striker Vaclav Kadlec to his ranks and will be hoping the 21-year-old can make an immediate impact.
The play-off round has a host of top European clubs entering it that includes 2002 winners Feyenoord. The Dutch side face Kuban Krasnodar as they attempt to reach the group stages of a European competition for the first time in four seasons.
Vincenzo Montella's Fiorentina side finished in fourth place in Serie A last season and have added the strike power of Mario Gomez and creativity of Joaquin to their squad in preparation for the new season.
Both players played in the UEFA Champions League last season and could feature when Fiorentina travel the short distance to Switzerland to face Grasshopper.
Ukrainian outfit Dynamo Kiev have participated in European competition for the last 26 seasons and face a trip to Kazakhstan to play Atkobe in their first leg.
Oleg Blokhin’s side have enjoyed a mixed start to the new league campaign – winning three of their opening six matches – but he will be expecting a victory over the Kazakh minnows.
Another 23 ties are due to take place on Thursday, while one side - Maccabi Tel Aviv - already have a place in the group stages.
The Israeli side were given a bye after PAOK were reinstated to the UEFA Champions League following Metalist Kharkiv's disqualification for alleged links to match-fixing.
|Coach: D. Uhrin jr.|
for Xisco Muñoz 42'
for D. Glishić 46'
for I. Dzaria 82'
|Inzaghi demands nastiness from Milan|
|MLS Review: Timbers triumph in Montreal, Dallas thwart Vancouver|
|Jovetic ready to lead City line - Pellegrini|
|Lewandowski impresses Ribery, Alaba|
|Colombian Primera A Review: Three clubs remain perfect, Atletico Nacional get off the mark|
|Rodgers: ´We can score goals´ without Suarez|
|Chilean Primera Division Review: Canales brace powers Universidad Chile|
|Atletico Madrid need penalties to edge past Earthquakes|
|Liga MX Review: Monterrey, America stay perfect|
|Paraguayan Primera Division Review: Capiata set pace|
|Brazilian Serie A Review: Cruzeiro win again, Kaka scores|
|Sterling goal sees Liverpool past Olympiacos|
|Peruvian Primera Division Review: Los Caimanes notch maiden win, Inti Gas claim top spot|
|CAF Champions League Review: Zamalek held, Vita Club leave it late|
|Jovetic at the double as Manchester City thrash Milan|
|Monk thrilled by Sigurdsson contribution|
|Lovren signs for Liverpool|
|Mourinho pleased with Olimpija test|
|Vertonghen eager to remain at Spurs|
|Sigurdsson marks Swansea return with a brace|
|Lewandowski, Rode help Bayern retain Telekom Cup|
|Immobile scores and suffers injury in Dortmund win|
|Costa scores on Chelsea debut|
|CAF Confederation Cup Review: Leopards de Dolisie 1 Real Bamako 2|
|Thai Premier League Review: Buriram pull clear, Police edge away from danger|
|Falcao nears Monaco return|
|CSL Review: Harbin Yiteng produce another upset, Evergrande stretch lead|
|Britton and Emnes to miss season-opener|
|Taylor-Fletcher strike sinks Everton|
|J.League Review: Chasing pack close on Urawa Reds, Tokushima Vortis secure rare win|
|Ancelotti expects fresh Bale to be even better|
|Simeone keen on Griezmann|
|Mazzarri refuses to set Inter targets|
|Lazio director targeted by fans|
|Dyche rules out Deeney move|
|Rummenigge: Bayern will never sack Guardiola|
|BREAKING NEWS: Arsenal to bring in Ospina|
|Pochettino quiet on Schneiderlin link|
|Vidic settling into Inter life|
|Van Gaal hints at Zaha United future|
|Di Maria will report for training - Ancelotti|
|Wilshere vows to answer critics|
|Rodgers expecting titles|
|Deila demands Celtic cutting edge|
|Rodgers: We won´t rush Lallana|
|Wenger: We have to be better against top-level teams|
|FIGC presidential candidate uses racist slur|
|MLS Review: Columbus claim second straight win, Toronto falter|
|Villa battle past Dynamo in Houston|
|United more efficient, says Garcia|
|Pedestrian Tottenham edge past Chicago Fire|
|Van Gaal bemoans display|
|CS Sfaxien 1 ES Tunis 0: Troussier era opens with a win|
|Icardi stars from the spot as Inter overcome Real Madrid|
|Arsenal upstaged by Red Bulls|
|Pre-Season Friendly Review: Rooney stars for United, Bayern reach Telekom final|
|In-form Rooney inspires Manchester United win|
|CAF Confederation Cup Review: Cotonsport on verge of progress|
|Ribery helps Bayern to penalty victory on return|
|Balzaretti suffers another injury blow|
|Puel confirms Ospina departure|
|Beckham backs Rodriguez to be Real hit|
|Bojan fails to inspire Stoke|
|Long on target as Hull held by Barnsley|
|Cardiff issue Medel warning|
|Ferreyra sorry for late Shakhtar return|
|Payet rules out Swansea move|
|Gilchrist nets winner as Burnley edge Accrington|
|Cazorla optimistic for new season|
|Celtic suffer St Pauli defeat|
|QPR lose on Ferdinand debut|
|Mashaba handed Bafana Bafana role|
|Van Aanholt eager to prove himself|
|Areola completes Bastia loan switch|
|Ospina imminent, but Szczesny gets Wenger´s backing|
|Reus happy with progress|
|Alleged spot-fixers released|
|Giuly: Mathieu can be the next Abidal|
|Allardyce hoping to keep hold of Morrison|
|Monk hails quality of Swansea additions|
|Van Gaal orders United players to speak English|
|Allardyce: We must improve|
|Campbell thrilled by Palace switch|
|Bojan drawn by Stoke style|
|Palace were wasteful, says Pulis|
|Van Gaal suits me - Cleverley|
|Newcastle stay perfect in NZ|
|Van Gaal prepared to wait for Strootman|
|West Brom overcome Sacramento|
|Colorado Rapids 3 Chivas USA 0: Hosts rise to third in the West|
|Gameiro brace adds to West Ham woes|
|Villas-Boas: Rodriguez best suited to no.10 role|
|Cazorla: I´m happy at Arsenal|
|Reina respects Liverpool contract|
|Lampard could move to Melbourne on loan|
|Galliani: Balotelli ´99.9 per cent´ staying|
|Own goal helps Palace win in Philadelphia|
|Mourinho: Shaw deal would have ´killed´ Chelsea|
|Al Ahli Benghazi 0 ES Setif 2: Visitors on verge of semi-final spot|
|Julio Cesar returns to QPR|
|Rooney wants to lead United|