PSV will look to extend their unbeaten start to the Eredivisie season against Go Ahead Eagles on Saturday, while Ajax host rivals Feyenoord.
PSV, the 2012-13 runners-up, have claimed all available points so far after winning 3-2 at ADO Den Haag and thrashing NEC 5-0 at the Philips Stadion on Saturday.
Teenage striker Zakaria Bakkali introduced himself to the PSV fans with three goals in the win over NEC, becoming the youngest ever Eredivisie player to net a hat-trick, while Georginio Wijnaldum scored the other two.
But Go Ahead Eagles will want to build on their last performance after picking up their first three points of the season with a narrow 2-1 victory over ADO, courtesy of a late goal from Marnix Kolder.
Ajax will hope to put Sunday's 3-2 defeat to AZ Alkmaar behind them with a victory in their first derby of the season after the Dutch champions twice threw away the lead last time out.
And Frank de Boer's side have a great opportunity to claim bragging rights after Feyenoord suffered their second successive defeat on Sunday to FC Twente.
The hosts took the lead through Graziano Pelle but went on to concede two penalties and have both Jordy van Deelen and Stefan de Vrij sent off during the 4-1 loss.
Twente will feel confident ahead of their home fixture this weekend as Utrecht visit De Grolsch Veste on the back of a 2-0 loss at Groningen, who are one of the four unbeaten teams this season.
The Euroborg outfit travel to Cambuur and NEC will host PEC Zwolle as both visiting sides look to preserve their 100 per cent records this season.
Heerenveen will hope Alfred Finnbogason can continue his early goalscoring form when Heracles visit on Sunday, after the striker notched his third goal during the 2-0 win at NAC Breda.
Elsewhere, Vitesse travel to Roda JC with new loan signing Lucas Piazon ready for his debut after the Brazilian followed Chelsea team-mates Patrick van Aanholt, Gael Kakuta and Cristian Cuevas to the GelreDome.
The visitors will want to get back to winning ways after a 4-2 defeat at RKC Waalwijk, who host AZ, in which Sander Duits netted two goals.
The other fixture this weekend will see NAC take on ADO at Rat Verlegh Stadion.
|Coach: P. Cocu|
for S. Arias 30'
for F. Jozefzoon 75'
for O. Hiljemark 83'
|Walker juggles music, football careers in Sweden|
|Song to face ´brother from another mother´ Fabregas|
|Adriano announces Le Havre deal|
|Pardew braced for Old Trafford test|
|Lescott unfazed by City reunion|
|Tskhadadze appointed Georgia coach|
|United to finish top three - Ferdinand|
|Allardyce: Stamford Bridge stalemate saved my job|
|Southampton need three January signings, says Watson|
|Liverpool can make Champions League, says fanzine editor|
|Walsh: Hull clash crucial for Leicester|
|Toure, Aubameyang and Enyeama make shortlist for African gong|
|Docherty backs Chelsea to win two-horse race|
|Liverpool could benefit from Hyypia influence - Scales|
|Saudi Arabia name Asian Cup squad|
|Forty-year-old Cahill no problem for Postecoglou|
|Wenger criticism baffles Redknapp|
|Leicester must strengthen in window - Walsh|
|United not title contenders - Docherty|
|Koeman: Southampton youngsters will get a chance|
|Dyche empathises with Liverpool striker crisis|
|Cagliari turn to Zola|
|Rooney thanks Van Gaal for Christmas break|
|Cruzeiro offer Paulinho Tottenham exit chance|
|Carlisle´s wife grateful to Burnley|
|Katebe called up to Zambia AFCON squad|
|Cape Verde name AFCON squad|
|Finke names much-changed Cameroon squad|
|Grant omits World Cup troublemakers for AFCON|
|Blackpool striker Ranger goes AWOL|
|Allardyce relishing Mourinho meeting|
|Ashley fails to increase Rangers stake|
|Crystal Palace v Southampton: Koeman calls for focus|
|Warnock targeting striker in January|
|Chelsea v West Ham: Adrian vows visitors will attack|
|Heskey signs short-term deal at Bolton|
|Everton v Stoke City: Martinez eyes strong form|
|Juninho defends David Luiz|
|Burnley v Liverpool: Dyche defends Rodgers ahead of Turf Moor test|
|Arsenal v QPR: Wenger eyes festive momentum|
|Liverpool are growing in confidence, says Rodgers|
|Redknapp: Austin future could depend on survival|
|Martinez wants Everton consistency|
|Barca want Neymar until 2020, says agent|
|Jones undeterred by pressure of Liverpool starting role|
|Allardyce ´knows how to beat managers´ - Carroll|
|Jones playing for a new contract|
|China select Evergrande spine for Asian Cup|
|A-League Preview: Koren tips City to build|
|Khedira keen to fight for Real spot|