Michael Carrick will miss England's friendly against Scotland due to an eye infection.
The Manchester United midfielder has withdrawn from Roy Hodgson's squad for the match at Wembley on Wednesday and has returned to his club.
Carrick, who has been capped 29 times by his country, established himself in Hodgson's first-choice team last season after being left out of the squad for the 2012 UEFA European Championships.
The 32-year-old enjoyed a superb 2012-13 campaign at club level and was nominated for the PFA Player of the Year award after helping United reclaim the Premier League title from rivals Manchester City.
The Old Trafford outfit get the defence of their crown under way with a trip to Swansea on Saturday and manager David Moyes now faces an anxious wait to discover if his playmaker will be fit to take part.
Carrick has made 320 appearances for United since joining from Tottenham in July 2006, scoring 21 goals.
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