Bayern Munich duo Bastian Schweinsteiger and Mario Goetze are key omissions from Germany's squad to face Paraguay on Wednesday.
The midfield pair have been hampered by injuries, with Schweinsteiger struggling with an ankle complaint, while Goetze steps-up his recovery after a groin problem.
And manager Joachim Loew has decided not to risk their fitness for the fixture at the Fritz-Walter-Stadion.
Schalke's 21-year-old midfielder Julian Draxler was in line to earn his seventh cap, but withdrew from the squad after injuring his Achilles tendon in the club's 3-3 draw with Hamburg.
Loew has recalled nine players from Bayern Munich and Borussia Dortmund who were left out of the country's two-match tour of the United States in June, after featuring in May's UEFA Champions League final.
Among those brought back are Bayern defenders Jerome Boateng and Philipp Lahm, while Dortmund midfielders Sven Bender and Marco Reus are also named.
And Loew was pleased to welcome back some familiar faces as they warm up with Wednesday's friendly ahead of vital FIFA World Cup qualifying fixtures in September and October.
"I am very pleased that for the first time in five months we have many of the players back who form the backbone of the team," he said.
"It is important to start well to start in a season which will end for us with the World Cup in Brazil."
Mario Gomez and Andre Schuerrle are both named in the squad, and Loew believes the pair will benefit from close-season moves to Fiorentina and Chelsea respectively.
"I'm sure both players will gain from their experiences abroad," he continued. "You can see that Schuerrle is in good hands with Jose Mourinho from the progress Mesut Oezil and Sami Khedira made under him."
An experimental Germany side lost their last fixture 4-3 against the United States in June.
But the three-time World Cup winners are in generally good shape, having gone on a nine-game unbeaten run previous to that defeat.
Paraguay manager Victor Genes has named a 21-man squad, including Barcelona's 17-year-old striker Antonio Sanabria, who is a reported transfer target for Premier League side Arsenal.
Liga MX outfit Toluca are well represented, with Richard Ortiz, Pablo Velazquez and Edgar Benitez all included.
Paraguay lost their last two fixtures, both World Cup qualifiers, against Ecuador and Chile, and they sit bottom of the South American qualifying table with eight points from 12 games.
|Coach: J. Löw|
for I. Gündogan 27'
for P. Mertesacker 46'
for M. Klose 54'
for M. Reus 62'
for T. Müller 81'
for M. Schmelzer 82'
|Van Persie wants United stay|
|UEFA Europa League: Tottenham 1 Benfica 3|
|UEFA Europa League: Juventus 1 Fiorentina 1|
|UEFA Europa League: Sevilla 0 Real Betis 2|
|UEFA Europa League: AZ 1 Anzhi 0|
|UEFA Europa League: Lyon 4 Viktoria Plzen 1|
|Castro bemoans disallowed goal|
|Ronaldo has helped me greatly, says Bale|
|The best team won, concedes Reina|
|FA defend handling of Anelka ´quenelle´ case|
|UEFA Europa League: Ludogorets 0 Valencia 3|
|UEFA Europa League: Porto 1 Napoli 0|
|UEFA Europa League: Basel 0 Red Bull Salzburg 0|
|Mulumbu: We need four or five wins to stay up|
|Premier League Preview: Aston Villa v Chelsea|
|La Liga Preview: Malaga v Real Madrid|
|Premier League Preview: Swansea City v West Brom|
|FA opt not to appeal Anelka ban|
|Premier League Preview: Stoke City v West Ham|
|Bundesliga Preview: Bayern Munich v Bayer Leverkusen|
|Benteke urges cup-final approach|
|Premier League Preview: Everton v Cardiff City|
|Premier League Preview: Southampton v Norwich City|
|Premier League Preview: Fulham v Newcastle United|
|Hughton ´disappointed´ to be only black manager|
|Lewandowski close to Dortmund comeback|
|Bellamy claims improvement under Solskjaer|
|Unbeaten run is not a priority - Alaba|
|Remy, Debuchy face injury lay-offs|
|Genoa can upset Juventus, says Antonelli|
|Every game a cup final, says Zaccardo|
|Pardew ´relieved´ not to lose job|
|League One Preview: Slade ready for Brentford test, Wolves face Shrewsbury|
|La Liga Preview: Atletico Madrid v Espanyol|
|Serie A Preview: Milan v Parma|
|Bundesliga Preview: Borussia Dortmund v Borussia Monchengladbach|
|Premier League Preview: Hull City v Manchester City|
|Serie A Preview: Bottom four go head-to-head, Chievo meet slumping Fiorentina|
|CSL Preview: Shenxin face second derby, Evergrande host Harbin|
|Serie A Preview: Verona v Inter|
|Championship Preview: Millwall face rivals Charlton, play-off battle intensifies|
|Gardner, Brown set for Sunderland returns|
|Gardner, Brown set for Sunderland returns|
|Premier League Preview: Sunderland v Crystal Palace|
|League Two Preview: York eye play-off push, Rochdale ready for derby|
|Allardyce aiming to pick up quick points|
|Gunter signs contract extension at Freiburg|
|Busquets: Title will be decided at Bernabeu|
|Hoeness receives three-and-a-half-year sentence|
|Ramsey out of Tottenham clash|
|Guarin focusing on future at Inter|
|Koeman interested in Swansea role, says agent|
|Stevens expecting more from Stuttgart|
|Agger: Liverpool can handle title pressure|
|Netherlands fall to lowest FIFA ranking in over a decade|
|Adler confident Hamburg can survive ´brutal´ season|
|Champions League still achievable for Everton, says Martinez|
|Zabaleta slams ´shocking´ decisions|
|Blanc: Europe starting to take note of PSG|
|Messi targets silverware|
|Sherwood hopes outburst will reinvigorate Tottenham|
|Martino: Barca must ride momentum|
|Liga MX Preview: Cruz Azul seek form reversal, Toluca in tow|
|Costa Rica Primera Division Wrap: Herediano stumble sends Deportivo Saprissa top|
|CONCACAF Champions League Wrap: Joy for MLS clubs|
|Copa Libertadores Wrap: Nacional Asuncion rise late, Botafogo beaten|
|J.League Preview: Kashima Antlers, Sagan Tosu in top-two tussle|
|Rooney wants United armband|
|Cousillas waves away Aguero fears|
|Messi: Barca progress never in doubt|
|Hyypia proud of defeated Leverkusen|
|Kompany: City´s time will come|
|Blanc unhappy with sluggish PSG start|
|SPL Wrap: Prolific May ends United run, Hibernian held|
|Football League Wrap: Wigan Athletic, Sheffield United avoid FA Cup hangovers|
|UEFA Champions League: Barcelona 2 Manchester City 1 (4-1 agg)|
|Rangers lift League One title|
|UEFA Champions League: Paris Saint-Germain 2 Bayer Leverkusen 1 (6-1 agg)|
|AFC Champions League Wrap: ´Lacklustre´ Guangzhou held, Ulsan win again|
|Montella takes heart from Juve defeat|
|La Liga Preview: Vallecano meet Almeria in crunch relegation clash, Valladolid visit Sevilla|
|Eredivisie Preview: In-form PSV out to dent Vitesse´s title hopes|
|Ligue 1 Preview: Evian host Valenciennes in crucial relegation clash|
|Falcao can make World Cup claims surgeon|
|Ronaldo mentoring Jese, says Pepe|
|UEFA investigate Bayern banners|
|Good hopeful over World Cup prospects|
|Lamela could return this season, claims Sherwood|
|Vermaelen unsure over Arsenal future|
|Cambiasso vows to play on despite uncertain Inter future|
|Castro: No favourites in Porto, Napoli tie|
|Sunderland hire Congerton as sporting director|
|Southampton appoint Krueger as chairman|
|Conte could rotate for Europa League|
|Labadie given 10-match ´biting´ ban|
|Rodgers has restored fear factor, says Fowler|
|Napoli can climb to second, says Reina|
|Newcastle should sack Pardew, say fan group|
|Monk pleased with Swansea performance levels|
|Hernanes backs Inter for top four|
|Cellino ´humiliated´ by Leeds saga|
|Sunderland need Fletcher, insists Poyet|
|Robben hits out at Wenger|
|Monchengladbach extend Favre contract|
|Returning Lucas seeking World Cup berth|
|Abbiati: Milan going in the wrong direction|
|West Brom suffer Brunt injury blow|
|Simeone warning inspired convincing win, says Filipe Luis|
|Agbonlahor eyeing 40-point mark|
|Beckenbauer concerned by Barca-esque Bayern|
|Rooney keen to captain club and country|
|Copa Libertadores Wrap: Bocanegra´s late show clinches draw for Atletico Nacional|
|CONCACAF Champions League: San Jose Earthquakes 1 Toluca 1|
|Urawa Reds apologise for racist banner|
|MLS Preview: Colorado to open campaign at Red Bulls|
|A-League Preview: Premier´s Plate within reach for Brisbane|
|Bayern Munich question Arsenal´s tactics|
|Bundesliga Preview: Struggling Leverkusen face biggest test|
|League Two Wrap: Torquay shock Rochdale, Chesterfield held|
|League One Wrap: Wolves break club record, Brentford and Orient successful|
|Milan were lacking psychologically, says Seedorf|