Celtic, Lyon and PSV will take leads into crucial away encounters in the second leg of the third round of UEFA Champions League qualifying.
A total of 15 ties will conclude this week, with the winners to enter the play-offs round where places in the group stage for Europe's premier club competition will be up for grabs.
Scottish champions Celtic failed to convert their dominance in a 1-0 win over Swedish outfit Elfsborg at Celtic Park last week.
And they may be made to rue their profligacy in front of goal on Wednesday against a side who have lost just one competitive match at home in 2013.
While Celtic are just one game into their league campaign - a late Anthony Stokes strike gave them a 2-1 win over Ross County on Saturday - Elfsborg have played 18 encounters in the Swedish Allsvenskan and sit sixth in the table.
Lyon will also hit the road with a one-goal advantage, gained in a 1-0 win over Switzerland's Grasshopper last week.
Milan Bisevac headed the winner for the Ligue 1 outfit, but they will also be wary due to their slender advantage as they prepare for the second leg fixture at Stadion Letzigrund in Zurich on Tuesday.
Eredivisie side PSV have more breathing space as they visit Zulte-Waregem of the Belgian First Division on Wednesday with a 2-0 lead.
Turkish Super Lig side Fenerbahce claimed a 1-1 draw at Salzburg and host the Austrian outfit on Tuesday, and Partizan of Serbia will attempt to overturn a 2-1 deficit against Ludogorets of Bulgaria on the same day.
Zenit of Russia won 1-0 at Nordsjaelland in Denmark last week and host the return leg, while Czech outfit Viktoria Plzen lead 4-0 ahead of a home fixture against Estonia's Kalju. Both of those games will take place on Wednesday.
Also this week, Croatia's Dinamo Zagreb and Switzerland's FC Basel travel with 1-0 leads, as they visit Sheriff of Moldova and Israel's Maccabi Tel Aviv respectively.
Other fixtures see Romania's Steaua Bucharest take a 2-0 lead into a home game against Georgia's Dinamo Tbilisi, while Ukraine's Metalist also lead by two goals and welcome PAOK Salonika of Greece.
APOEL of Cyprus and Denmark's Molde are both at home against Slovenia's Maribor and Poland's Legia Warsaw, with both legs locked at 1-1.
Iceland's FH will attempt to overturn a 1-0 deficit when they host Austria Vienna, but Albania's Skenderbeu Force appears even tougher as they trail Kazakhstan's Shakhter Karagandy 3-0.
|Coach: M. Skibbe|
for F. Feltscher 69'
for T. Nzuzi 70'
for I. Hajrović 79'
|Bertrand set for lay-off after knee surgery|
|BREAKING NEWS: New five-year Juve deal for Marchisio|
|Allegri extends Juve contract|
|Koeman reiterates Alderweireld interest|
|Valencia bag Bakkali|
|New York City FC complete Pirlo capture|
|Panama v Haiti: Collat ready to challenge the best of CONCACAF|
|UEFA Champions League Preview: Harrison eyes TNS progression|
|FIFA sanctions Yemen for fielding ineligible player|
|Toulouse rubbish Ben Yedder exit reports|
|Mourinho ´knows what he´s doing´ with Falcao signing|
|Watford shell out club-record fee for Capoue|
|Braafheid signs Lazio extension|
|Nani finalises Fenerbahce move|
|Liverpool confirm O´Driscoll appointment|
|Liverpool have to start better - Lucas|
|USA simply too good - Sasaki|
|Portland Timbers 1 San Jose Earthquakes 0: Jewsbury wins it in stoppage time|
|No move yet for Van Persie|
|Lloyd wins Golden Ball, Silver Boot awards|
|Mascherano: I never grabbed Banega|
|Dunga requested Brazil not appeal Neymar´s suspension|
|United States 5 Japan 2: Lloyd stars with hat-trick|
|Fiorentina deny Inter criticism|
|Nani relishing Fenerbahce opportunity|
|Newcastle hold talks over Northampton youngster|
|Cuadrado´s agent plays down Chelsea exit rumours|
|Liverpool´s Alberto set for Deportivo loan|
|Leverkusen suffer surprise defeat, Stuttgart hit six|
|Inter ´dismayed´ at Fiorentina vice-president´s Salah Twitter outburst|
|Blaszczykowski ruled out of Dortmund´s Asia tour|
|Gerrard gets the beers in for LA Galaxy fans|
|De Gea coy over Real links|
|Former Brazil star Carlos handed Delhi reins|
|Ciftci will not push through Celtic switch – agent|
|In-demand Mitrovic considering Roma offer|
|Lehmann calls on Cech to ´get over´ Chelsea|
|Marlos double sinks Monaco|
|Mauritius 0 South Africa 2 (agg 0-5): Bafana set up Angola qualifier|
|Keane relishing Gerrard arrival|
|Palace confirm Cabaye interest|
|Hamburg bring in Spahic after head-butt ban|
|Blatter hits out at France and Germany over World Cup votes|
|Sanchez: World Cup exit spurred Chile to Copa glory|
|Jojic makes Cologne switch, Santana move falls through|
|Carrillo keen to get going at Monaco|
|Micronesia thrashed 38-0 as Fiji triumph in Olympic qualifier|
|Schalke stunned by ´machine´ Caicara|
|MLS Review: Keane shines at Gerrard´s Galaxy unveiling|
|Counter-attacking the key for Japan|
|Jimenez happy at Atletico|
|Gerrard predicts ´successful future´ with Galaxy|
|Iniesta can´t see Real selling Ramos|
|Keshi sacked as Nigeria coach|
|Three finals, three defeats for Messi, Mascherano|
|Nani close to Fenerbahce move|
|Sampaoli revels in ´unbelievable joy´|
|Bravo: Copa victory a dream|
|Martino: Argentina should have won|
|Chile 0 Argentina 0 (4-1 on penalties): Hosts end trophy drought|
|Germany 0 England 1 (after extra time): England make World Cup history|
|Kenya 0 Ethiopia 0 (agg 0-2): Hosts sent out of CHAN qualifiers after second penalty miss|
|Dortmund put 17 past Olympians, Bremen hand out thrashing|
|Dinamo Zagreb confirm arrests of coach and club president|
|I didn´t know who Wimbledon guest Klopp was - Brown|
|LeBron James backs Liverpool captain Henderson for FIFA 16 cover.|
|Ramos: I am not negotiating with anyone|
|Valencia complete Mina swoop|
|United States v Japan: US seek final redemption|
|Hanousek consigns Celtic to defeat|
|Roma confirm Dzeko interest|
|Arsenal forward Podolski completes Galatasaray switch|
|Warm Dortmund welcome delights Tuchel|
|Silva vows to fight for Madrid place|
|Mancini hints at Shaqiri and Santon departures|
|Bojan raring to go after return from injury|
|Babel backs Firmino to shine at Liverpool|
|Falcao must wait to impress, warns Chelsea favourite|
|Bartomeu: Deal in place for Turan|
|Parejo re-signs with Valencia|
|MLS Review: Sounders return to winning ways|
|Klinsmann unhappy with USA performance|
|High hopes for Paraguay - Diaz|
|Gareca: More to come from Peru|
|Gerrard had European offers|
|Argentina out to spoil Chile´s party - Martino|
|Sampaoli: Chile won´t change style|
|Di Maria will come good at United - Rojo|
|Peru 2 Paraguay 0: Gareca´s men finish third at Copa|
|United States 4 Guatemala 0: Klinsmann´s men win comfortably|
|´I’d prefer no-one to know my name´ - Bassett|