Celtic, Lyon and PSV will take leads into crucial away encounters in the second leg of the third round of UEFA Champions League qualifying.
A total of 15 ties will conclude this week, with the winners to enter the play-offs round where places in the group stage for Europe's premier club competition will be up for grabs.
Scottish champions Celtic failed to convert their dominance in a 1-0 win over Swedish outfit Elfsborg at Celtic Park last week.
And they may be made to rue their profligacy in front of goal on Wednesday against a side who have lost just one competitive match at home in 2013.
While Celtic are just one game into their league campaign - a late Anthony Stokes strike gave them a 2-1 win over Ross County on Saturday - Elfsborg have played 18 encounters in the Swedish Allsvenskan and sit sixth in the table.
Lyon will also hit the road with a one-goal advantage, gained in a 1-0 win over Switzerland's Grasshopper last week.
Milan Bisevac headed the winner for the Ligue 1 outfit, but they will also be wary due to their slender advantage as they prepare for the second leg fixture at Stadion Letzigrund in Zurich on Tuesday.
Eredivisie side PSV have more breathing space as they visit Zulte-Waregem of the Belgian First Division on Wednesday with a 2-0 lead.
Turkish Super Lig side Fenerbahce claimed a 1-1 draw at Salzburg and host the Austrian outfit on Tuesday, and Partizan of Serbia will attempt to overturn a 2-1 deficit against Ludogorets of Bulgaria on the same day.
Zenit of Russia won 1-0 at Nordsjaelland in Denmark last week and host the return leg, while Czech outfit Viktoria Plzen lead 4-0 ahead of a home fixture against Estonia's Kalju. Both of those games will take place on Wednesday.
Also this week, Croatia's Dinamo Zagreb and Switzerland's FC Basel travel with 1-0 leads, as they visit Sheriff of Moldova and Israel's Maccabi Tel Aviv respectively.
Other fixtures see Romania's Steaua Bucharest take a 2-0 lead into a home game against Georgia's Dinamo Tbilisi, while Ukraine's Metalist also lead by two goals and welcome PAOK Salonika of Greece.
APOEL of Cyprus and Denmark's Molde are both at home against Slovenia's Maribor and Poland's Legia Warsaw, with both legs locked at 1-1.
Iceland's FH will attempt to overturn a 1-0 deficit when they host Austria Vienna, but Albania's Skenderbeu Force appears even tougher as they trail Kazakhstan's Shakhter Karagandy 3-0.
|Coach: M. Skibbe|
for F. Feltscher 69'
for T. Nzuzi 70'
for I. Hajrović 79'
|Messi vows to stay at Barcelona ´for as long as they want me´|
|Cafu adamant Neymar will become world´s best|
|I´m just taking a sabbatical - Van Gaal denies he´s retired|
|Not even Gerrard won Premier League - Buttner says he´s not a United flop|
|Samper ignored Wenger as Barca midfielder rejected Arsenal|
|Pleased Pioli wants more from Inter|
|Evergrande boss Scolari dismisses Turan links|
|Klopp seeks legal advice over Matip|
|Marseille complete Sanson move|
|Inter 3 Bologna 2: Candreva prevents remarkable turnaround in Coppa Italia thriller|
|FA Cup Review: Non-league Lincoln stun Ipswich, Burnley and Palace through|
|Gabon v Burkina Faso: Aubameyang says hosts have learned from Guinea-Bissau setback|
|Mali 0 Egypt 0: El-Hadary makes history in stalemate|
|El-Hadary oldest AFCON player ever - 44-year-old Egypt goalkeeper makes history|
|Reus and Gotze on target but Bender injured in Dortmund win|
|Toure shunning lavish China interest to stay at City, says Seluk|
|Rahman´s AFCON in the balance, says Ghana boss Grant|
|Just 14 goals conceded and nine clean sheets - How Vertonghen blow could impact Tottenham|
|Ghana 1 Uganda 0: Andre Ayew hands Black Stars nervy victory|
|Swansea snap up Carroll and Olsson in double swoop|
|All is forgiven? - Costa trains with full Chelsea squad after reported Conte bust-up|
|I would throw myself off a bridge for Luis Enrique - Rakitic dismisses Barca rift rumours|
|Was Juventus´ new logo inspired by tennis star?|
|Smooth sailing for Liverpool in Plymouth? Klopp expects tough test|
|Demichelis re-joins Malaga until end of season|
|Cameroon v Guinea-Bissau: Broos urges new heroes to emerge|
|Boxing champ hits Carragher with Chinese Super League comeback prank|
|Zidane backs Navas and defends Benzema as Madrid aim to bounce back|
|Deportivo bring in Kakuta from Hebei after CSL rule changes|
|Matip could miss eight games without doing anything wrong - Klopp|
|United trigger Valencia´s contract extension|
|Ronaldo returns to Real Madrid´s Copa squad|
|FA fine Sagna for Instagram post|
|Nedved does not foresee more January business for Juventus|
|Rafinha injury blow for Barcelona|
|Villas-Boas fumes at CSL foreign player crackdown|
|Ibrahimovic invaluable to Manchester United youngsters - Rashford|
|Robben rejected China move|
|A-League review: Phoenix rise to the occasion to end Victory´s streak|
|Van Gaal slams English media over treatment at Manchester United|
|Mignolet: Liverpool in better position to win title than in 2013-14|
|Giroud wants Premier League title but understands China temptations|
|Tianjin forced to scrap moves for Costa, Benzema, Cavani and Falcao|
|My goal was better than Mkhitaryan´s - Giroud|
|Pochettino not interested in Argentina job|
|Kane: Tottenham can win Premier League|
|Corinthians dreaming of Drogba - Paulo Roberto|
|Coutinho calls for Liverpool focus|
|Chiellini compares Pogba to LeBron and Bolt|
|Maradona to become Napoli ambassador|
|Mihajlovic furious after Torino collapse|
|Icardi has offers from China - Wanda Nara|
|Pogba can cope with pressure - Ibrahimovic|
|´My half-time words will stay in the dressing room´ - Montella annoyed with AC Milan|
|Juventus unveil dramatic change to club logo - but not everyone´s a fan|
|´I do not think I will return to coaching´ - Van Gaal set to call it quits|
|Torino 2 AC Milan 2: Bacca caps thrilling comeback as hosts pay the penalty|
|DR Congo 1 Morocco 0: Kabananga pounces on blunder to give 10 men the points|
|´Happy and comfortable´ Sanchez dismisses Arsenal exit talk|
|How much?! West Ham flop Simone Zaza could cost Valencia €20m|
|Mali v Egypt: Salah leads Pharaohs´ bid for AFCON glory|
|Sevilla concede they ´cannot force´ sporting director Monchi to stay|
|Ivory Coast 0 Togo 0: Reigning champions held to opening draw by Adebayor and co.|
|Goalkeeping woes, Stones and tactical confusion - How Guardiola is making life difficult for himself|
|Ozil and Sanchez can be persuaded to stay - Cech|
|Pogba: I rejected Barcelona and Real Madrid|
|Ghana v Uganda: Gyan dreams of first trophy since 1982|
|Chiellini: Juventus a work in progress|
|Robben agrees Bayern renewal until 2018|
|Hazard: Goals do not matter to me|
|Bennell pleads not guilty to eight child sex offences|
|Muller fed up with debate over Bayern role|
|Wenger glad Sanchez is not ´a Costa problem´|
|Flick resigns as DFB´s sporting director|
|Gomis ´can´t wait´ to welcome Payet to Marseille|
|Chinese FA changes foreign player rules after ´irrational´ spending|
|Like father, like son: Justin Kluivert follows in dad´s footsteps|
|´No reason to lose him´ - Marotta rubbishes talk of Allegri exit|
|Courtois: We don´t need Costa|
|Kane: Tottenham players won´t go to China|
|Noble ´angry and disappointed´ with Payet|
|Klopp furious over Matip uncertainty|
|Wenger surprised by tight Premier League|
|´Money is not everything´ - Conte issues warning amid China speculation|
|Fiorentina defeat a ´bad setback´ - Allegri|
|´This will elevate this group of players´ - Sampaoli revels in Sevilla late show|