Familiarity will not be a problem for either side when Real Madrid play host to Lyon in Champions League Group D at the Bernabeu.
The teams will come face to face in the tournament for the third season in a row on Tuesday, as Madrid coach Jose Mourinho attempts to sew up qualification to the next stage.
The Spanish giants have maximum points from their opening two games - a 1-0 victory over Dinamo Zagreb and a 3-0 thumping of Ajax Amsterdam seeing them on top of the group.
Cristiano Ronaldo has continued his imperious form this season, and with Gonzalo Higuain scoring a hat-trick against Real Betis in La Liga at the weekend, Mourinho will have his best strikers at his disposal against Lyon.
The French side, who are second in Group D with four points after a 2-0 win over Dinamo Zagreb, face an uphill task at the Bernabeu.
Former Arsenal midfielder Remi Garde will be looking to strikers Bafetimbi Gomis and Bakary Kone to add to the scoresheet against the nine-time European champions.
Meanwhile, Dutch champions Ajax are pinning their qualification hopes on a win in Croatia as they play away against Dinamo Zagreb.
After a goalless opening draw against Lyon, a 3-0 hammering by Real Madrid at the Bernabeu has left Ajax's qualification hopes hanging by a thread.
But they will take confidence from their recent record against Dinamo Zagreb, having never lost nor conceded a goal against the Croatian champions.
They will have to do it, however, without striker Kolbeinn Sigthorsson, who will miss the remainder of the Champions League campaign with a stress fracture in his right ankle.
The 21-year-old has scored five goals in eight Eredivisie games since signing from AZ Alkmaar in the summer.
Ajax are currently third in the group, five points behind Real Madrid and three behind Lyon.