Bundesliga preview: Weaker Bremen face champions
Werder Bremen host Bundesliga champions Borussia Dortmund on Friday while leaders Bayern Munich welcome Hertha Berlin.
Second-placed Bremen have 16 points from their opening eight games after an impressive start to the campaign but will be without Marko Arnautovic, who was sent off in the loss to Hannover in the last round.
Bremen boss Thomas Schaaf will also have to do without injured defenders Leon-Aderemi Balogun and Mikael Silvestre, midfielders Ozkan Yildirim and Tim Borowski as well as striker Denni Avdic.
Dortmund manager Juergen Klopp praised Bremen's fast start to the season believing they have improved markedly on last season's 13th-placed finish in the league and also confirmed star Lucas Barrios was still in doubt for the trip to Weserstadion.
"Barrios will be able to play much more than he did against Augsburg, but he is not yet ready for 90 minutes at full throttle," Klopp said.
League leaders Bayern host 10th-placed Hertha Berlin as they look to extend their 11-game unbeaten streak on Saturday.
Bayern are still without winger Arjen Robben for the clash and will be looking to take all three points after they dropped points to Hoffenheim in a goalless draw following ten-straight victories.
The last time Hertha defeated Bayern away from home was in 1977 and with the Bavarian outfit in imperious form - having scored 28 goals in their last 11 games and conceded none - that wait looks set to continue.
Bayern goalkeeper Manuel Neuer has not conceded a goal for 1,018 minutes breaking the previous club record set by Oliver Kahn.
Aside from Robben, Bayern have no fresh injury concerns with winger Franck Ribery and striker Ivica Olic fit to play.
In other games on Saturday, Mainz will be looking for a first win in seven matches when they host Augsburg, with the newly promoted club still after their first win in the Bundesliga.
Borussia Monchengladbach will entertain Bayer Leverkusen, Schalke host Kaiserslautern, Wolfsburg are at home to Nurnberg while Stuttgart face a tough task against Hoffenheim.
On Sunday, Hannover visit Cologne while Freiburg will host Frank Arnesen's first and last game in charge of Hamburg, with former Bayern Munich player Thorsten Fink to take charge of the bottom-placed club next week.