A Dmitri Bulykin goal gave Bayer 04 Leverkusen victory at FC Zenit St. Petersburg but was nowhere near enough to cancel out the Russian side's 4-1 first-leg lead which secured their place in the UEFA Cup semi-finals.

Dick Advocaat's Zenit took a pragmatic appoach to defending their aggregate advantage and found their feet once Leverkusen had gained an early lifeline through former Russian international Bulykin's powerful header. Zenit's second-half pressure earned a late penalty, only for Anatoliy Tymoschuk to be denied by René Adler.