Real Madrid came from a goal down to beat 10-man Levante 4-2 on Sunday and extend their lead to 10 points at the top of La Liga.Visitors Levante opened the scoring just five minutes from kick-off at the Santiago Bernabeu, when Gustavo Cabral headed home from Francisco Farinos' free-kick.
Real Madrid hold a healthy seven-point lead atop La Liga ahead of Sunday's meeting with Levante, while Barcelona visit Osasuna.
Despite speculation suggesting Jose Mourinho will depart the Santiago Bernabeu at the end of the season, an 18th-minute winner from Sergio Ramos saw Real continue their fine form with a 1-0 victory at Getafe last time out.
Mourinho has been linked with a return to the English Premier League, but Real forward Jose Callejon believes the Portuguese tactician will remain with the La Liga giants.
"I do not believe Mourinho will go at the end of the season, because he is happy here," Callejon said on Wednesday.
"He really wants to work hard and to do things well. I think he is calm and really wants to win a lot of trophies."
They host a Levante side clinging to fourth spot, winless in six outings after a stunning start to the campaign, which included a shock 1-0 win over Real in September.
Meanwhile, Barca's chase of their rivals continues with a trip to ninth-placed Osasuna.
Several players - including Andres Iniesta, Sergio Busquets and Pedro - are hopeful of recovering from injury in time for Saturday's encounter.
Another slip-up from Barca could cost them any chance of retaining their title.
In other matches, third-placed Valencia, 11 points adrift of Barca, take on lowly Sporting Gijon at Estadio Mestalla on Sunday.
Inaki Tejada has been confirmed as Sporting Gijon boss until the end of the season, with his team's 1-1 draw at home to Osasuna bringing them to within four points of safety.
Espanyol will be out to extend their unbeaten league run to eight matches when they host bottom-placed Real Zaragoza.
Atletico Madrid, who have kept six consecutive clean sheets and are unbeaten under Diego Simeone, visit Racing Santander, while Athletic Bilbao travel to Real Betis, both on Saturday.
Villarreal will look to continue their resurgence under Jose Molina when they host Granada on Sunday.
Elsewhere, Malaga face Mallorca, mid-table sides Getafe and Rayo Vallecano meet and Real Sociedad host Sevilla.