Groningen had a good start in Eindhoven as bad defense from Andre Ooijer allowed Tim Matavz to score the opening goal in the third minute.
But the hosts levelled with a distance shot from 17-year-old Zakaria Labyad in the 26th minute and a free kick from Balazs Dzsudzsak put PSV ahead three minutes after the break.
Labyad, in his first appearance in PSV's starting line-up, went on to add a second in the 84th minute after a shot from Stijn Wuytens came back from the post.
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