Lopez put Lyon ahead in the 10th minute when Bordeaux defender Michael Ciani made a defensive mistake.
Miralem Pjanic's weak free-kick was easily blocked by the wall but the ball was hoofed back into the box where Ciani completely misjudged his clearance, with Mathieu Bodmer thumping in a shot for Lopez to divert home.
But Bordeaux leveled four minutes later Chamakh scored his fourth Champions League goal of the season by heading home from a Yoann Gourcuff delivery.
However, Brazilian winger Michel Bastos made it 2-1 from a tight angle in the 32nd.
Another defensive lapse meant Benoit Tremoulinas's failure to head away Pjanic's cross, Michel Bastos slotting in at the far post.
And Lopez sealed the victory in the 77th with a penalty, after Aly Cissokho's shot certainly hit Chalme's arm, sending goalkeeper Cedric Carrasso the wrong way.
LYON, France (AFP) - Victors and vanquished took pride in a memorable night for French football after Lyon defeated Bordeaux 3-1 in the first leg of their Champions League quarter-final here.
Early goals for both sides set the scene for a match of occasionally frantic intensity and there was consolation for Bordeaux in both the quality of their football and the role they played in an engaging first ever all-French Champions League knockout match.
"I saw a really good match," said Bordeaux coach Laurent Blanc after Tuesday's game at the Stade Gerland.
"I haven't seen Bordeaux play like that for a long time. It felt like the match went really quickly.
"There were lots of chances for the two sides, who both played at a very high level. Paradoxically, I'm very happy with the level of our play. I took a lot of pleasure from watching the match and seeing my team play."
Marouane Chamakh's header cancelled out Lisandro Lopez's 10th-minute opener for Lyon, but the hosts went in front again in the 32nd minute when Michel Bastos exploited an error from Benoit Tremoulinas to score.
A finely poised second half saw Bordeaux twice come close to snatching an equaliser - and a precious away goal - with Chamakh drawing a spectacular save from Hugo Lloris and Wendel smashing a volley against the crossbar.
Lyon's third goal arrived via a penalty from Lisandro in the 77th minute after Mathieu Chalme was penalised for handling the ball in the penalty area.
The Bordeaux right-back expressed his dismay at the decision but said his side would take heart from the nature of their performance.
"You can see the score, but we can be proud of the way we played away from home, particularly as it was at Lyon," said Chalme.
"We were disappointed in the changing room but everyone believes we can do it because we showed some really good things.
"The two teams were in Champions League mode and played some lovely football, but Lyon were more clinical. It's still achievable for us."
Bordeaux playmaker Yoann Gourcuff, elected France's Player of the Year after leading the side to their first Ligue 1 title in 10 years last season, was also keen to focus on the positives from Les Girondins' performance.
"We'll try to play the same way (in the second leg) by being more efficient defensively and going forward," said the France international.
"Even though we've made things difficult for ourselves, there's still a return match."
Victory puts Lyon on the threshold of reaching the Champions League semi-finals for the first time in their history but they remain cautious about the second leg on April 7.
"Our objective will be to score over there," said full-back Anthony Reveillere.
"A two-goal lead gives us a little cushion. It's better than 2-1, but we would have liked to have got a fourth. We can't afford to lose our heads in the return leg."
Lyon's Champions League campaign has already seen them overcome European giants including Liverpool, Fiorentina and, in a momentous last-16 tie, Real Madrid, but midfielder Jeremy Toulalan warned against looking too far ahead.
"It'll be pretty much the same match over there (in Bordeaux), because we need to assert ourselves in attack, as we did tonight," he said.
"We'll have to produce the same kind of match as we did against Real Madrid (a 1-1 draw in the second leg), but every game is different.
"Tonight (Tuesday), we've got a good result, but it's still difficult."
(GSM) - The Champions League quarter final clash between French rivals Olympique Lyon and Girondins Bordeaux may well be decided in the former's favor after a 3-1 win in Tuesday's first leg.
Ten minutes had passed in Lyon when the hosts went ahead through Liandro, who netted from close range after Mathieu Bodmer fired across the face of the goal.
But the home side's lead would not last as Bordeaux levelled four minutes later. Yoann Gourcuff beat Jeremy Toulalan on the wing and crossed in for Marouane Chamakh to head in from about six meters.
Lyon kept their cool however and restored their lead in the 32nd minute as Michel Bastos converted a left-winged cross from Miralem Pjanic for 2-1.
And the home side went on to extend their lead in the 77th minute. Bordeaux' Chalmé handled the ball in the penalty area and Lisandro sent the keeper the wrong way to convert the following spot kick.
PARIS (AFP) - Bordeaux coach Laurent Blanc has told his players to shrug off the disappointment of their League Cup final defeat and focus on Tuesday's Champions League quarter-final first leg at Lyon.
Holders Bordeaux were defeated 3-1 by Marseille in Saturday's final in Paris and have also seen a nine-point lead in the French first division whittled down to goal difference by Montpellier.
Defeat in a physical match to Marseille was far from ideal preparation for their trip to domestic rivals Lyon and Blanc says the reigning French champions must get the loss out of their system as quickly as possible.
"We're lucky in a way because we have an important match on Tuesday in the quarter-finals of the Champions League," said Blanc, whose side have not reached this stage of Europe's top club tournament since 1988.
"We'll have to bounce back quickly, get over this disappointment and throw ourselves into this important match.
"If we had a week to prepare, we'd be able to assess everything. Even though it's always better to win before a match like this, we haven't got the time. We have to get our heads in the right place."
Blanc made his priorities clear during Saturday's final by withdrawing playmaker Yoann Gourcuff and striker Marouane Chamakh with 20 minutes still to play and the score 2-0.
"We had planned certain things, but not necessarily in that way," admitted Blanc, who guided Les Girondins to the league title last season.
"I'd said it was the paradox of the final. We had to prepare for it while preparing for the next match at the same time.
"I had several options open to me. I chose one. We'll find out on Tuesday if I was right or not."
Bordeaux skipper Alou Diarra misses Tuesday's match at the Stade Gerland through suspension, while centre-back Marc Planus remains sidelined with a knee ligament injury.
Lyon, who eliminated Real Madrid in the previous round, geared up for the visit of Bordeaux with a 2-0 win over bottom club Grenoble on Saturday.
It was a welcome fillip for Claude Puel's side, after a damaging 2-1 defeat to Marseille in the league the previous weekend and an unedifying spat with Bordeaux over the scheduling of the match with Grenoble, which was originally due to take place on Friday.
"It's always better to win the match before the Champions League," said Puel. "Even though we want to prepare ourselves well psychologically, your head can always be turned towards Tuesday's match.
"It's for that reason that we had to deal with Saturday's match well."
Lyon, seven-time French champions from 2002 to 2008, will be competing in their fourth Champions League quarter-final but have never progressed to the last four.
They are unbeaten at home in the competition this season, though, and Bosnian midfielder Miralem Pjanic anticipates a tight first leg.
"It's particularly important not to concede any goals," said the 19-year-old. "We know what happens to us when we don't concede. It gives us confidence."
A late Chamakh header gave Bordeaux a 1-0 victory when the sides last met in the league in December and Pjanic concedes that his side are gunning for revenge.
"The game was very competitive and very even," he recalled.
"We would have deserved a draw. We want to get a kind of revenge against them but we have to remember that they are two very different matches."
Full-back Francois Clerc will not feature for Lyon despite having resumed training following surgery on a knee problem, but centre-back Jean-Alain Boumsong could make the bench after overcoming a calf injury.
The second leg in Bordeaux takes place on April 7, with the winners of the quarter-final between Bayern Munich and Manchester United awaiting the victors in the last four.
LYON, France (AFP) - Bordeaux coach Laurent Blanc and Lyon counterpart Claude Puel have dismissed suggestions that the balance of power in French football is at stake in their Champions League quarter-final.
Blanc's team, who face Puel's side in the first leg here on Tuesday, ended seven years of domestic domination by Lyon last season when they won the French championship for the first time since 1999.
They are well placed to repeat the trick this year as well, leading Ligue 1 with 10 games to play and two matches in hand.
Their clash with Lyon, the first between two French clubs at this stage of the Champions League, has been billed as an opportunity for Bordeaux to replace their opponents as the pre-eminent force in French football.
Blanc, though, is keen to claim underdog status for his side.
"There's no supremacy at stake," he said in his pre-match press conference here on Monday.
"Lyon are clearly superior to us. What Lyon have done over the last eight or 10 years is exceptional.
"Everyone tries to shrug off the favourites tag but at a European level there is no comparison between the Girondins and Lyon, for now."
Puel echoed Blanc's sentiments by insisting that his charges were focusing purely on their objective of reaching the semi-finals for the first time in the club's history.
"It's really the possibility of getting to the semis that's important," said the former Lille boss.
"The squad are more focused on this than the fact we're facing Bordeaux."
Tuesday's encounter at Lyon's Stade Gerland will contain few surprises for the players on either side, but Blanc says his team cannot afford to lose their focus for a second.
"The big advantage is that two teams know each other very well and we're not expecting any big surprises with the tactics or the shape of the team," said the former France centre-back.
"The first leg away from home is important. I said so before the match in Greece against Olympiakos (in the previous round).
"We'll have to put in a big performance against an opponent that knocked out Real Madrid."
Bordeaux won 1-0 when the sides last met in the league in December but Blanc insists the European game will be approached differently.
"We can anticipate their tactics a bit, but the Champions League is a different competition," he said.
"There will be a result and a second leg. In the big European matches, in the first 15 to 20 minutes, everyone has a duel to win to mark his territory before the game can unfold."
Bordeaux go into the match on the back of a spiky and combative 3-1 defeat to Marseille in Saturday's League Cup final and Puel believes the stricter standard of officiating in Europe's top club competition means a similar level of physicality will not be tolerated.
"We're in a European confrontation with a German referee (Felix Brych) who will control things well," said the Lyon boss.
"We might find ourselves in a game that's a bit less full-blooded than the battles we saw in the final of the League Cup."
Turning to the match, Puel said he would be pleased to take a one-goal lead to the Stade Chaban-Delmas next week.
Asked for his ideal result, he responded: "A 1-0 victory, like against Real in the first leg of the round of 16, or even 2-0 or 2-1."