Fiorentina scored twice in the second half to sink nine-man Cagliari.
The win improved the home side's hopes of European football while keeping Cagliari on the edge of the qualification picture.
Fiorentina opened the scoring through Manuel Pasqual before Alessandro Agostini was sent off for Cagliari for a second bookable offence.
Juan Vargas extended Fiorentina's lead before Daniele Ragatzu gave the visitors hope of claiming a share of the points.
However, Michele Canini was the second Cagliari player sent off when he was shown a straight red card with a minute left.
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